Dosage & Administration
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Invokamet
(canagliflozin / metformin)
canagliflozin 150 MG / metformin hydrochloride 1000 MG Oral Tablet [Invokamet]
BLACK BOX WARNING
Dosage & administration
* Individualize starting dose based on the patient's current regimen and renal function ( 2.2, 2.3, 2.4)
* Initiation of INVOKAMET or INVOKAMET XR is not recommended in patients with an eGFR less than 45 mL/min/1.73 m
2
, due to the metformin component ( 2.4)
* INVOKAMET: one tablet, twice daily with meals, recommended starting dose of canagliflozin is 50 mg twice daily and metformin HCl 500 mg twice daily ( 2.2)
* INVOKAMET XR: two tablets, once daily with the morning meal. Swallow whole. Never crush, cut, or chew ( 2.2)
* Canagliflozin dose can be increased to a total daily dose of 300 mg in patients tolerating 100 mg who have an eGFR of 60 mL/min/1.73 m
2
or greater and require additional glycemic control. Do not exceed a total daily canagliflozin dose of 300 mg ( 2.2)
* Gradually escalate metformin HCl dose to reduce the gastrointestinal side effects while not exceeding a total daily dose of 2,000 mg ( 2.3)
* Assess renal function before initiating and as clinically indicated ( 2.1, 2.3)
* Dose adjustment for patients with renal impairment may be required ( 2.4)
* Adjust canagliflozin dose when taken with an UDP-Glucuronosyltransferase (UGT) inducer ( 2.5, 7.2)
* May need to be discontinued at time of, or prior to, iodinated contrast imaging procedures ( 2.6)
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Invokamet prescribing information
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Invokamet FAQs
How is the dosage of Invokamet?
Invokamet is available in 1 dosages, including 150-1,000 mg Tab
What does Invokamet treat?
Invokamet treats Type 2 Diabetes Mellitus
What is Invokamet made of?
Invokamet contains canagliflozin / metformin which is a Biguanide
How Is Invokamet Administered?
Invokamet is administered as a Oral Pill
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