Ruconest

(C1 esterase inhibitor (recombinant))
NO BOXED WARNING

Dosage & Administration

For Intravenous Use Only.

•Reconstitute each vial (2100 U) by adding 14 mL sterile Water for Injection per vial to obtain a solution of 150 U per mL. ( 2.3)•Administer the reconstituted solution at room temperature as a slow intravenous injection over approximately 5 minutes. ( 2.3)•Appropriately trained patients may self-administer upon recognition of an HAE attack. ( 2.3)

Recommended dose of RUCONEST for an acute attack

Body weight

RUCONEST Dose for Intravenous Injection

Volume (mL) of Reconstituted Solution (150 U/mL) to be Administered

< 84 kg

50 U per kg

Body weight in kg divided by 3

≥ 84 kg

4200 U (2 vials)

28 mL

If the attack symptoms persist, an additional (second) dose can be administered at the recommended dose level.  Do not exceed 4200 U per dose.  No more than two doses should be administered within a 24 hour period.

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