For Intravenous Use Only.
•Reconstitute each vial (2100 U) by adding 14 mL sterile Water for Injection per vial to obtain a solution of 150 U per mL. ( 2.3)•Administer the reconstituted solution at room temperature as a slow intravenous injection over approximately 5 minutes. ( 2.3)•Appropriately trained patients may self-administer upon recognition of an HAE attack. ( 2.3)
Recommended dose of RUCONEST for an acute attack
Body weight | RUCONEST Dose for Intravenous Injection | Volume (mL) of Reconstituted Solution (150 U/mL) to be Administered |
< 84 kg | 50 U per kg | Body weight in kg divided by 3 |
≥ 84 kg | 4200 U (2 vials) | 28 mL |
If the attack symptoms persist, an additional (second) dose can be administered at the recommended dose level. Do not exceed 4200 U per dose. No more than two doses should be administered within a 24 hour period.