<section class="Section" data-sectioncode="34089-3"><a name="LINK_2c8e4016-3376-4164-bb3b-b7547946b92d"></a><a name="section-8"></a><p></p><h1>11 DESCRIPTION</h1><p class="First">Fremanezumab-vfrm is a fully humanized IgG2Δa/kappa monoclonal antibody specific for calcitonin gene-related peptide (CGRP) ligand. Fremanezumab-vfrm is produced by recombinant DNA technology in Chinese hamster ovary (CHO) cells. The antibody consists of 1324 amino acids and has a molecular weight of approximately 148 kDa.</p><p>AJOVY (fremanezumab-vfrm) injection is a sterile, preservative-free, clear to opalescent, colorless to slightly yellow solution for subcutaneous injection, supplied in a single-dose 225 mg/1.5 mL prefilled autoinjector and a single-dose 225 mg/1.5 mL prefilled syringe. </p><p>Each prefilled autoinjector or prefilled syringe delivers 1.5 mL of solution containing 225 mg fremanezumab-vfrm, disodium ethylenediaminetetraacetic acid dihydrate (EDTA) (0.204 mg), L-histidine (0.815 mg), L-histidine hydrochloride monohydrate (3.93 mg), polysorbate-80 (0.3 mg), sucrose (99 mg), and Water for Injection, and has a pH of 5.5.</p></section>

AJOVY

1.5 ML fremanezumab-vfrm 150 MG/ML Auto-Injector

1.5 ML fremanezumab-vfrm 150 MG/ML Auto-Injector [Ajovy]

1.5 ML fremanezumab-vfrm 150 MG/ML Prefilled Syringe

1.5 ML fremanezumab-vfrm 150 MG/ML Prefilled Syringe [Ajovy]

Ajovy

fremanezumab

Migraine Disorders

Migraine with Aura

Migraine without Aura

<section class="Section" data-sectioncode="34089-3"><a name="S11"></a><a name="section-10"></a><p></p><h1>11 DESCRIPTION</h1><p class="First">NURTEC ODT contains rimegepant sulfate, a calcitonin gene-related peptide receptor antagonist. Rimegepant sulfate is described chemically as (5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)-1-piperidinecarboxylate hemisulfate sesquihydrate and its structural formula is:</p><p><img alt="Chemical Structure" src="nurtec-02.jpg"/></p><p>Its empirical formula is C <span class="Sub">28</span>H <span class="Sub">28</span>F <span class="Sub">2</span>N <span class="Sub">6</span>O <span class="Sub">3</span> 0.5 H <span class="Sub">2</span>SO <span class="Sub">4</span> 1.5 H <span class="Sub">2</span>O, representing a molecular weight of 610.63. Rimegepant free base has a molecular weight of 534.56. Rimegepant sulfate is a white to off-white, crystalline solid that is slightly soluble in water. </p><p>NURTEC ODT (orally disintegrating tablets) is for sublingual or oral use and contains 85.7 mg rimegepant sulfate, equivalent to 75 mg rimegepant free base, and the following inactive ingredients: benzyl alcohol, eucalyptol, gelatin, limonene, mannitol, menthol, menthone, menthyl acetate, sucralose, and vanillin.</p></section>

NURTEC ODT

Nurtec

rimegepant

rimegepant 75 MG Disintegrating Oral Tablet

rimegepant 75 MG Disintegrating Oral Tablet [Nurtec]

Ajovy is a prescription medication that can be self-injected once a month or once every three months under the skin to prevent migraine headaches. The most commonly reported side effect is injection site reactions. Ajovy does not seem to cause constipation. Additionally, there are no known drug interactions.

Ajovy is FDA approved for the following indications: Migraine prevention. 


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Enroll in Patient Savings Program 

Efficacy 

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About Ajovy 

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Taking Ajovy 

Patient Stories 

Patient Resources: Patients Considering Ajovy 

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Instructions For Use (Prefilled Syringe) : Migraine Prevention 

Instructions For Use (Prefilled Autoinjector): Migraine Prevention 

Doctor Discussion Guide: Patients Considering Ajovy

Migraine Tracker 

Nurtec ODT is a medication that can be placed under or onto the tongue to treat migraine symptoms in adults. When taken every other day, it can also be used to prevent episodic migraine. Nurtec ODT works by blocking CGRP, a protein believed to contribute to migraine attacks by causing pain, blood vessel dilation, and inflammation. The medication is well-tolerated, with less than 2% of individuals reporting nausea.

Nurtec ODT is FDA approved for the following indications: Migraine and Migraine prevention. 


Ajovy®(fremanezumab)	Nurtec®(rimegepant)

Prescription Only Ajovy is a prescription medication that can be self-injected once a month or once every three months under the skin to prevent migraine headaches. The most commonly reported side...	Prescription Only Nurtec ODT is a medication that can be placed under or onto the tongue to treat migraine symptoms in adults. When taken every other day, it can also be used to prevent episodic...
Dosage & Administration
Administration
Subcutaneous. Learn more.	Oral . Learn more.
Dosing
225 mg monthly or 675 mg every 3 months (as three consecutive injections of 225 mg each). Learn more.	Acute treatment of migraine: 75 mg as needed. Preventive treatment of episodic migraine: 75 mg every other day. Maximum daily dose: 75 mg.. Learn more.
Latin Shorthand
225 mg/mo or 675 mg q3mo. Learn more.	Acute treatment of Migraine: 75 mg PRN. Preventive treatment of Episodic Migraine: 75 mg qod.. Learn more.
Adverse Reactions
The most common adverse reactions (≥5% and greater than placebo) were injection site reactions.. Learn more.	Acute treatment of migraine: the adverse reaction reported in ≥ 1% of patients treated with NURTEC ODT is nausea. Preventive treatment of episodic migraine: adverse reactions reported in ≥ 2% for rimegepant and ≥ 1% higher than placebo are nausea and abdominal pain/dyspepsia.. Learn more.
Financial Assistance
Out-Of-Pocket Costs With Copay Card
$5. Learn more.	$0. Learn more.
Annual Cap
Patient specific maximum benefit.. Learn more.	Learn more.
Assistance Expiration
12/31/2023. Learn more.	Learn more.
Generics
No lower-cost generic available	No lower-cost generic available

Ajovy® Alternatives