Migraine Disorders

Migraine with Aura

Migraine without Aura

<section class="Section" data-sectioncode="34089-3"><a name="S11"></a><a name="section-10"></a><h1>11 DESCRIPTION</h1>NURTEC ODT contains rimegepant sulfate, a calcitonin gene-related peptide receptor antagonist. Rimegepant sulfate is described chemically as (5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)-1-piperidinecarboxylate hemisulfate sesquihydrate and its structural formula is:<img alt="Chemical Structure" src="nurtec-02.jpg"/>Its empirical formula is C 28H 28F 2N 6O 3 0.5 H 2SO 4 1.5 H 2O, representing a molecular weight of 610.63. Rimegepant free base has a molecular weight of 534.56. Rimegepant sulfate is a white to off-white, crystalline solid that is slightly soluble in water. NURTEC ODT (orally disintegrating tablets) is for sublingual or oral use and contains 85.7 mg rimegepant sulfate, equivalent to 75 mg rimegepant free base, and the following inactive ingredients: benzyl alcohol, eucalyptol, gelatin, limonene, mannitol, menthol, menthone, menthyl acetate, sucralose, and vanillin.</section>

NURTEC ODT

Nurtec

rimegepant

rimegepant 75 MG Disintegrating Oral Tablet

rimegepant 75 MG Disintegrating Oral Tablet [Nurtec]

<section class="Section" data-sectioncode="34089-3"><a name="section-10"></a><h1>11        DESCRIPTION</h1>The active ingredient of UBRELVY is ubrogepant, a calcitonin gene-related peptide (CGRP) receptor antagonist. The chemical name of ubrogepant is (3'S)-N-((3S,5S,6R)-6-methyl-2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)piperidin-3-yl)-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-carboxamide and has the following structural formula:<img alt="The following structural formula for UBRELVY is ubrogepant, a calcitonin gene-related peptide (CGRP) receptor antagonist. The chemical name of ubrogepant is (3'S)-N-((3S,5S,6R)-6-methyl-2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)piperidin-3-yl)-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-carboxamide." src="ubrelvy-01.jpg"/>The molecular formula is C29H26F3N5O3 and molecular weight is 549.6. Ubrogepant is a white to off-white powder. It is freely soluble in ethanol, methanol, acetone, and acetonitrile; and is practically insoluble in water.UBRELVY is available as tablets for oral administration containing 50 mg or 100 mg ubrogepant. The inactive ingredients include colloidal silicon dioxide, croscarmellose sodium, mannitol, microcrystalline cellulose, polyvinylpyrrolidone vinyl acetate copolymer, sodium chloride, sodium stearyl fumarate, and vitamin E polyethylene glycol succinate.</section>

UBRELVY

Ubrelvy

ubrogepant

ubrogepant 100 MG Oral Tablet

ubrogepant 100 MG Oral Tablet [Ubrelvy]

ubrogepant 50 MG Oral Tablet

ubrogepant 50 MG Oral Tablet [Ubrelvy]

Nurtec ODT is a medication that can be placed under or onto the tongue to treat migraine symptoms in adults. When taken every other day, it can also be used to prevent episodic migraine. Nurtec ODT works by blocking CGRP, a protein believed to contribute to migraine attacks by causing pain, blood vessel dilation, and inflammation. The medication is well-tolerated, with less than 2% of individuals reporting nausea.

Nurtec ODT is FDA approved for the following indications: Migraine and Migraine prevention. 


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Ubrelvy is a medication that adults can use to treat acute migraine attacks. It works by blocking CGRP, a protein believed to contribute to migraine attacks by causing pain, blood vessel dilation, and inflammation. Ubrelvy is well-tolerated, with less than 5% of individuals reporting side effects such as nausea, somnolence, and dry mouth. Ubrelvy does not prevent migraines.

Ubrelvy is FDA approved for the following indications: Migraine. 


Nurtec®(rimegepant)	Ubrelvy®(ubrogepant)

Prescription Only Nurtec ODT is a medication that can be placed under or onto the tongue to treat migraine symptoms in adults. When taken every other day, it can also be used to prevent episodic...	Prescription Only Ubrelvy is a medication that adults can use to treat acute migraine attacks. It works by blocking CGRP, a protein believed to contribute to migraine attacks by causing pain, blood...
Dosage & Administration
Administration
Oral . Learn more.	Oral. Learn more.
Dosing
Acute treatment of migraine: 75 mg as needed. Preventive treatment of episodic migraine: 75 mg every other day. Maximum daily dose: 75 mg.. Learn more.	50 mg or 100 mg as needed. Maximum daily dose: 200 mg. Severe Hepatic or Severe Renal Impairment: 50 mg.. Learn more.
Latin Shorthand
Acute treatment of Migraine: 75 mg PRN. Preventive treatment of Episodic Migraine: 75 mg qod.. Learn more.	50 mg PRN or 100 mg PRN. Severe Renal Impairment: 50mg.. Learn more.
Adverse Reactions
Acute treatment of migraine: the adverse reaction reported in ≥ 1% of patients treated with NURTEC ODT is nausea. Preventive treatment of episodic migraine: adverse reactions reported in ≥ 2% for rimegepant and ≥ 1% higher than placebo are nausea and abdominal pain/dyspepsia.. Learn more.	The most common adverse reactions (at least 2% and greater than placebo) were nausea and somnolence.. Learn more.
Financial Assistance
Out-Of-Pocket Costs With Copay Card
$0. Learn more.	$0. Learn more.
Annual Cap
Learn more.	Maximum savings of $50 per pill for up to 13 prescription fills.. Learn more.
Assistance Expiration
Learn more.	13 prescription fills. Learn more.
Generics
No lower-cost generic available	No lower-cost generic available

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