Actemra

(tocilizumab)
0.9 ML tocilizumab 180 MG/ML Auto-Injector [Actemra]0.9 ML tocilizumab 180 MG/ML Prefilled Syringe [Actemra]
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Dosage & administration

For RA, pJIA and sJIA, ACTEMRA may be used alone or in combination with methotrexate: and in RA, other DMARDs may be used.

General Administration and Dosing Information

Rheumatoid Arthritis

Recommended Adult Intravenous Dosage:

When used in combination with DMARDs or as monotherapy the recommended starting dose is 4 mg per kg every 4 weeks followed by an increase to 8 mg per kg every 4 weeks based on clinical response.

Recommended Adult Subcutaneous Dosage:

Patients less than 100 kg weight162 mg administered subcutaneously every other week, followed by an increase to every week based on clinical response
Patients at or above 100 kg weight162 mg administered subcutaneously every week

Giant Cell Arteritis

Recommended Adult Intravenous Dosage:

The recommended dose is 6 mg per kg every 4 weeks in combination with a tapering course of glucocorticoids. ACTEMRA can be used alone following discontinuation of glucocorticoids.

Recommended Adult Subcutaneous Dosage:

The recommended dose is 162 mg given once every week as a subcutaneous injection, in combination with a tapering course of glucocorticoids.

A dose of 162 mg given once every other week as a subcutaneous injection, in combination with a tapering course of glucocorticoids, may be prescribed based on clinical considerations.

ACTEMRA can be used alone following discontinuation of glucocorticoids.

Systemic Sclerosis-Associated Interstitial Lung Disease (SSc-ILD)

Recommended Adult Subcutaneous Dosage:

The recommended dose of ACTEMRA for adult patients with SSc-ILD is 162 mg given once every week as a subcutaneous injection.

Polyarticular Juvenile Idiopathic Arthritis

Recommended Intravenous PJIA Dosage Every 4 Weeks
Patients less than 30 kg weight10 mg per kg
Patients at or above 30 kg weight8 mg per kg
Recommended Subcutaneous PJIA Dosage
Patients less than 30 kg weight162 mg once every three weeks
Patients at or above 30 kg weight162 mg once every two weeks

Systemic Juvenile Idiopathic Arthritis

Recommended Intravenous SJIA Dosage Every 2 Weeks
Patients less than 30 kg weight12 mg per kg
Patients at or above 30 kg weight8 mg per kg
Recommended Subcutaneous SJIA Dosage
Patients less than 30 kg weight162 mg every two weeks
Patients at or above 30 kg weight162 mg every week

Cytokine Release Syndrome

Recommended Intravenous CRS Dosage
Patients less than 30 kg weight12 mg per kg
Patients at or above 30 kg weight8 mg per kg
Alone or in combination with corticosteroids.

Coronavirus Disease 2019

The recommended dosage of ACTEMRA for adult patients with COVID-19 is 8 mg per kg administered by a 60-minute intravenous infusion.

Administration of Intravenous formulation


Administration of Subcutaneous formulation


Dose Modifications


drug label

Actemra prescribing information

prior authorization

Actemra prior authorization resources

Most recent Actemra prior authorization forms

View By Payer
Updated: Jun 04, 2023Blue Cross Blue Shield of Michigan - FEP Actemra SC Prior Authorization Form (Medical Benefit)
Updated: Jun 04, 2023Blue Cross Blue Shield of Michigan - FEP Actemra IV Prior Authorization Form (Medical Benefit)
Updated: May 30, 2023Cigna - Actemra Prior Authorization Form
Updated: May 29, 2023Blue Cross Blue Shield of Michigan - Actemra Prior Authorization Form (Medical Benefit)
Updated: May 25, 2023Independence Health - Value Formulary Immune Modulating Therapy Prior Authorization Form
Updated: May 25, 2023Independence Health - Select Formulary Immune Modulating Therapy Prior Authorization Form
Updated: May 23, 2023Aetna - Actemra Prior Authorization Form
Updated: May 22, 2023Aetna - Medicare Part B Actemra Prior Authorization Form

OTHER
Complete Letter of Medical Necessity

OTHER
Coverage Authorization Appeals
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Benefits investigation

PDF
Rheumatology Subsequent Verification Program (RSVP) Enrollment Form

PDF
Actemra Prescriber Service Form
Actemra Prescriber Service Form - Online
Learn More

pharmacy

Actemra preferred pharmacy

OTHER
Pharmacy List

financial assistance

Actemra financial assistance options

Co-pay savings program

commercial only

PDF
Actemra Prescriber Service Form
Actemra Prescriber Service Form - Online
Enroll in Patient Savings Program
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Bridge program

commercial only

PDF
Actemra Prescriber Service Form
Actemra Prescriber Service Form - Online

OTHER
ACT Fast Bridge Program
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Foundation programs

under insured
no insurance
goverment insurance
65+

PDF
Genentech Patient Assistance Foundation Prescriber Form
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patient education

Actemra patient education

Getting started on Actemra

BRAND PAGE
Instructions For Use: Rheumatoid Arthritis
ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

BRAND PAGE
Instructions For Use: Systemic Sclerosis-Associated Interstitial Lung Disease (SSc-ILD)
ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

BRAND PAGE
Instructions For Use: Giant Cell Arteritis (GCA)
ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

BRAND PAGE
Instructions For Use: Polyarticular Juvenile Idiopathic Arthritis (PJIA)
ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

BRAND PAGE
Instructions For Use: Systemic Juvenile Idiopathic Arthritis (SJIA)
ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

BRAND PAGE
Instructions For Use: Cytokine Release Syndrome (CRS)
ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link
To share resource; ask patient to:
1.Pull out phone
2.Open camera
3.Scan QR code with camera
4.Tap link

Patient toolkit

BRAND PAGE
About Actemra: RA
ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

OTHER
Actemra Treatment Options: RA
ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

OTHER
Receiving Actemra IV Infusion: RA
ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

VIDEO
Patient Stories: RA
ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

PDF
Doctor Discussion Guide: RA
ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

PDF
Patient Brochure: RA
ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

PDF
Patient Brochure (Spanish): RA
ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

BRAND PAGE
About Actemra: SSc-ILD
ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

BRAND PAGE
Side Effects: SSc-ILD
ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

OTHER
View How to Take Actemra: SSc-ILD
ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

OTHER
Patient Resources: SSc-ILD
ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link
Sign Up For Travel Pack & Sharps Container: SSc-ILD
ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

PDF
Patient Brochure: SSc-ILD
ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

BRAND PAGE
About Actemra: GCA
ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

OTHER
View How to Take Actemra: GCA
ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

OTHER
Receiving Actemra Infusion: GCA
ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link