Dosage & Administration Biomarker testing Drug label Prior authorization Financial assistance

Avastin

(bevacizumab)

16 ML bevacizumab 25 MG/ML Injection [Avastin]4 ML bevacizumab 25 MG/ML Injection [Avastin]

NO BLACK BOX WARNING

Dosage & administration

Withhold for at least 28 days prior to elective surgery. Do not administer Avastin for 28 days following major surgery and until adequate wound healing.

Metastatic colorectal cancer

* 5 mg/kg every 2 weeks with bolus-IFL
* 10 mg/kg every 2 weeks with FOLFOX4
* 5 mg/ kg every 2 weeks or 7.5 mg/kg every 3 weeks with fluoropyrimidine-irinotecan- or fluoropyrimidine-oxaliplatin-based chemotherapy after progression on a first-line bevacizumab product-containing regimen

First-line non–squamous non–small cell lung cancer

* 15 mg/kg every 3 weeks with carboplatin and paclitaxel

Recurrent glioblastoma

* 10 mg/kg every 2 weeks

Metastatic renal cell carcinoma ( 2.5)

* 10 mg/kg every 2 weeks with interferon alfa

Persistent, recurrent, or metastatic cervical cancer

* 15 mg/kg every 3 weeks with paclitaxel and cisplatin, or paclitaxel and topotecan

Stage III or IV epithelial ovarian, fallopian tube or primary peritoneal cancer following initial surgical resection

* 15 mg/kg every 3 weeks with carboplatin and paclitaxel for up to 6 cycles, followed by 15 mg/kg every 3 weeks as a single agent, for a total of up to 22 cycles

Platinum-resistant recurrent epithelial ovarian, fallopian tube or primary peritoneal cancer

* 10 mg/kg every 2 weeks with paclitaxel, pegylated liposomal doxorubicin, or topotecan given every week
* 15 mg/kg every 3 weeks with topotecan given every 3 weeks

Platinum-sensitive recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer

* 15 mg/kg every 3 weeks with carboplatin and paclitaxel for 6-8 cycles, followed by 15 mg/kg every 3 weeks as a single agent
* 15 mg/kg every 3 weeks with carboplatin and gemcitabine for 6-10 cycles, followed by 15 mg/kg every 3 weeks as a single agent

Hepatocellular Carcinoma

* 15 mg/kg after administration of 1,200 mg of atezolizumab every 3 weeks

Administer as an intravenous infusion after dilution. See full Prescribing Information for preparation and administration instructions and dosage modifications for adverse reactions

Avastin clinical details

Genetic testing requirements were obtained from the NCCN guidelines for each cancer type.

drug label

Avastin prescribing information

Contact Medical Science Liaison Report Adverse Event

prior authorization

Avastin prior authorization resources

Most recent Avastin prior authorization forms

View By Payer

Updated: Jun 06, 2023Highmark BCBS Northeastern NY - Outpatient Avastin Prior Authorization Form (Medical Benefit)

Updated: Jun 06, 2023Highmark BCBS Western NY - Outpatient Avastin Prior Authorization Form (Medical Benefit)

Updated: Jun 05, 2023Highmark BCBS West Virginia - Outpatient Avastin Prior Authorization Form (Medical Benefit)

Updated: Jun 05, 2023Highmark BCBS Delaware - Outpatient Avastin Prior Authorization Form (Medical Benefit)

Updated: Jun 05, 2023Highmark BCBS Central PA - Outpatient Avastin Prior Authorization Form (Medical Benefit)

Updated: Jun 04, 2023Highmark BCBS Western PA - Outpatient Avastin Prior Authorization Form (Medical Benefit)

Updated: May 30, 2023Cigna - Avastin Prior Authorization Form

Updated: May 29, 2023Blue Cross Blue Shield of Michigan - Oncology Biosimilar Prior Authorization Form (Medical Benefit)

Updated: May 22, 2023Aetna - Medicare Part B Avastin Prior Authorization Form

OTHERComplete Letter of Medical Necessity

OTHERCoverage Authorization Appeals

PDFPatient Consent Form

PDFPatient Consent Form - Spanish

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Benefits investigation

PDFAvastin Prescriber Service & Patient Consent Form

Avastin Prescriber Service Form - Online Portal

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Reimbursement help (FRM)

Receive Assistance from an FRM Regarding Reimbursement Information

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financial assistance

Avastin financial assistance options

Co-pay savings program

commercial only

PDFAvastin Prescriber Service & Patient Consent Form

Enroll in Patient Savings Program

Avastin Prescriber Service Form - Online Portal

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Overview

Reduce patient OOP costs for drug (and occasionally for drug administration/infusion costs or drug-related test costs)

Patient benefit

A portion (or all) of patient OOP (deductible, copay), typically up to monthly and/or annual max

Patient eligibility

Patient must enroll or activate (may permit HCPs to enroll on patient’s behalf for HCP-administered drugs)
Generally, must have commercial insurance (rarely, may permit uninsured patients to use)
May never be used with government insurance

How to sign up

Cards may be downloadable digital cards or hard copies
Some pharmacos offer debit cards with pre-loaded copay benefit
Typically, available through multiple channels (e.g., rep to HCP to patient; pharmacy to patient; patient via website, Hub live agent, or copay vendor (live agent or IVR); patient and HCP via Hub enrollment form)
Some HCP-administered product programs permit HCPs to enroll on a patient’s behalf through via Hub form

Foundation programs

under insured

no insurance

goverment insurance

65+

PDFAvastin Prescriber Service & Patient Consent Form

PDFGenentech Patient Foundation Application Form (1/2)

PDFGenentech Patient Foundation Application Form (2/2) - Patient Consent Form

Avastin Prescriber Service Form - Online Portal

Learn More

Overview

Charitable 501(c)(3) organizations provide direct cost-sharing and other support (e.g., travel, counseling) through disease-state funds to indigent patients on first-come first-served basis
These organizations may receive financial contributions from drug manaufacturers for particular disease-state funds that cannot provide funds directly to patients - the foundation must be independent/unaligned

Patient benefit

Patients apply for grants that cover a portion (or all) of their out-of-pocket costs (deductibles and co-pays) until the grant is exhausted

Patient eligibility

Patients must apply and meet eligibility criteria including income level (typically a multiple of federal poverty line), specific diagnosis, insurance status, etc.

How to sign up

Patients submit proof of out-of-pocket drug costs to charities for reimbursement

patient education

Avastin patient education

Getting started on Avastin

To share resource; ask patient to:

1.Pull out phone

2.Open camera

3.Scan QR code with camera

4.Tap link