What is the dosage of Avastin?

Avastin is available in 2 dosages, including 25 mg/ml Injection 4 ml and 25 mg/ml Injection 16 ml

What is Avastin mechanism of action?

Avastin mechanism of action is Vascular Endothelial Growth Factor-directed Antibody Interactions or Vascular Endothelial Growth Factor Inhibitors

Avastin Prescribing & Dosing Schedule

Q: What does Avastin treat?

Avastin treats Carcinoma, Non-Small-Cell Lung, Uterine Cervical Neoplasms, Fallopian Tube Neoplasms, Glioblastoma, Kidney Neoplasms, Ovarian Neoplasms, Peritoneal Neoplasms and Colorectal Neoplasms

Q: What is Avastin made of?

Avastin contains bevacizumab which is a Vascular Endothelial Growth Factor Inhibitor

Q: How is Avastin administered?

Avastin is administered as a Injectable

Last Update: Oct, 07 2024

Avastin (bevacizumab)

Avastin 100 MG in 4 ML Injection

NO BOXED WARNING

Dosage & Administration

Withhold for at least 28 days prior to elective surgery. Do not administer Avastin for 28 days following major surgery and until adequate wound healing.

Metastatic colorectal cancer

* 5 mg/kg every 2 weeks with bolus-IFL
* 10 mg/kg every 2 weeks with FOLFOX4
* 5 mg/ kg every 2 weeks or 7.5 mg/kg every 3 weeks with fluoropyrimidine-irinotecan- or fluoropyrimidine-oxaliplatin-based chemotherapy after progression on a first-line bevacizumab product-containing regimen

First-line non–squamous non–small cell lung cancer

* 15 mg/kg every 3 weeks with carboplatin and paclitaxel

Recurrent glioblastoma

* 10 mg/kg every 2 weeks

Metastatic renal cell carcinoma ( 2.5)

* 10 mg/kg every 2 weeks with interferon alfa

Persistent, recurrent, or metastatic cervical cancer

* 15 mg/kg every 3 weeks with paclitaxel and cisplatin, or paclitaxel and topotecan

Stage III or IV epithelial ovarian, fallopian tube or primary peritoneal cancer following initial surgical resection

* 15 mg/kg every 3 weeks with carboplatin and paclitaxel for up to 6 cycles, followed by 15 mg/kg every 3 weeks as a single agent, for a total of up to 22 cycles

Platinum-resistant recurrent epithelial ovarian, fallopian tube or primary peritoneal cancer

* 10 mg/kg every 2 weeks with paclitaxel, pegylated liposomal doxorubicin, or topotecan given every week
* 15 mg/kg every 3 weeks with topotecan given every 3 weeks

Platinum-sensitive recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer

* 15 mg/kg every 3 weeks with carboplatin and paclitaxel for 6-8 cycles, followed by 15 mg/kg every 3 weeks as a single agent
* 15 mg/kg every 3 weeks with carboplatin and gemcitabine for 6-10 cycles, followed by 15 mg/kg every 3 weeks as a single agent

Hepatocellular Carcinoma

* 15 mg/kg after administration of 1,200 mg of atezolizumab every 3 weeks

Administer as an intravenous infusion after dilution. See full Prescribing Information for preparation and administration instructions and dosage modifications for adverse reactions

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Avastin Prescribing Information

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Avastin Prior Authorization Resources

Most recent state uniform prior authorization forms

Verified: Sep 24, 2024Arizona - Uniform Prior Authorization Form

Verified: Sep 24, 2024Colorado - Uniform Prior Authorization Form

Verified: Sep 24, 2024Hawaii - Uniform Prior Authorization Form

Verified: Sep 24, 2024Illinois - Uniform Prior Authorization Form

Verified: Sep 24, 2024Indiana - Uniform Prior Authorization Form

Verified: Sep 24, 2024Louisiana - Uniform Prior Authorization Form

Verified: Sep 24, 2024Minnesota - Uniform Prior Authorization Form

Verified: Sep 24, 2024New Hampshire - Uniform Prior Authorization Form

Verified: Sep 24, 2024New Mexico - Uniform Prior Authorization Form

Verified: Sep 24, 2024Oregon - Uniform Prior Authorization Form

Verified: Sep 24, 2024Texas - Uniform Prior Authorization Form

Verified: Oct 05, 2024Washington - Uniform Prior Authorization Form

Verified: Oct 05, 2024Wisconsin - Uniform Prior Authorization Form

Coverage Authorization Appeals

Complete Letter of Medical Necessity

Patient Consent Form

Patient Consent Form - Spanish

Benefits investigation

Avastin Prescriber Service & Patient Consent Form

Avastin Prescriber Service Form - Online Portal

Reimbursement help (FRM)

Receive Assistance from an FRM Regarding Reimbursement Information

Avastin Financial Assistance Options

Copay savings program

Avastin Prescriber Service & Patient Consent Form

Enroll in Patient Savings Program

Avastin Prescriber Service Form - Online Portal

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Overview

Reduce patient OOP costs for drug (and occasionally for drug administration/infusion costs or drug-related test costs)

Patient benefit

A portion (or all) of patient OOP (deductible, copay), typically up to monthly and/or annual max

Patient eligibility

Patient must enroll or activate (may permit HCPs to enroll on patient’s behalf for HCP-administered drugs)
Generally, must have commercial insurance (rarely, may permit uninsured patients to use)
May never be used with government insurance

How to sign up

Cards may be downloadable digital cards or hard copies
Some pharmacos offer debit cards with pre-loaded copay benefit
Typically, available through multiple channels (e.g., rep to HCP to patient; pharmacy to patient; patient via website, Hub live agent, or copay vendor (live agent or IVR); patient and HCP via Hub enrollment form)
Some HCP-administered product programs permit HCPs to enroll on a patient’s behalf through via Hub form

Foundation programs

Avastin Prescriber Service & Patient Consent Form

Genentech Patient Foundation Application Form (1/2)

Genentech Patient Foundation Application Form (2/2) - Patient Consent Form

Avastin Prescriber Service Form - Online Portal

Learn More

Overview

Charitable 501(c)(3) organizations provide direct cost-sharing and other support (e.g., travel, counseling) through disease-state funds to indigent patients on first-come first-served basis
These organizations may receive financial contributions from drug manaufacturers for particular disease-state funds that cannot provide funds directly to patients - the foundation must be independent/unaligned

Patient benefit

Patients apply for grants that cover a portion (or all) of their out-of-pocket costs (deductibles and copays) until the grant is exhausted

Patient eligibility

Patients must apply and meet eligibility criteria including income level (typically a multiple of federal poverty line), specific diagnosis, insurance status, etc.