Cinryze

(C1 esterase inhibitor)

Cinryze 500 UNT Injection

NO BLACK BOX WARNING

Dosage & administration

For Intravenous Use Only

* Prior to reconstitution, protect from light.
* A silicone-free syringe is recommended.
* Store at 36°F to 77°F (2°C to 25°C). Do not freeze.
* To obtain a 500 International Units (IU) CINRYZE dose, reconstitute one CINRYZE vial with one vial of Sterile Water for Injection, USP (5 mL). To obtain a 1,000 IU CINRYZE dose, reconstitute two CINRYZE vials with two vials of Sterile Water for Injection, USP (5 mL each). Use aseptic sterile technique.
* Administer at room temperature within 3 hours of reconstitution.

Routine Prophylaxis Dosing

Adults and adolescents (12 years old and above)

Indication	Dose	Infusion rate
* Doses up to 2,000 IU (not exceeding 80 IU/kg) every 3 or 4 days may be considered based on individual patient response.
Routine prophylaxis against HAE attacks	1,000 IU Intravenous every 3 or 4 days *	1 mL/min (10 min)

Children (6 to 11 years old)

Indication	Dose	Infusion rate
* Doses up to 1,000 IU every 3 or 4 days may be considered based on individual patient response.
Routine prophylaxis against HAE attacks	500 IU Intravenous every 3 or 4 days *	1 mL/min (5 min)

drug label

Cinryze prescribing information

Contact Medical Science Liaison Report Adverse Event

prior authorization

Cinryze prior authorization resources

Most recent Cinryze prior authorization forms

View By Payer

Updated: Jun 04, 2023Blue Cross Blue Shield of Michigan - FEP Cinryze Prior Authorization Form (Medical Benefit)

Updated: May 30, 2023Cigna - Hereditary Angioedema Prior Authorization Form

Updated: May 29, 2023Blue Cross Blue Shield of Michigan - Hereditary Angioedema Prior Authorization Form (Medical Benefit)

Updated: May 24, 2023Aetna - Cinryze Prior Authorization Form

Updated: May 23, 2023Aetna - Medicare Part B Cinryze Prior Authorization Form

PDFComplete Letter of Medical Necessity

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Benefits investigation

PDFOne Path Enrollment Form

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financial assistance

Cinryze financial assistance options

Co-pay savings program

commercial only

PDFOne Path Enrollment Form

OTHEREnroll in Patient Savings Program

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Overview

Reduce patient OOP costs for drug (and occasionally for drug administration/infusion costs or drug-related test costs)

Patient benefit

A portion (or all) of patient OOP (deductible, copay), typically up to monthly and/or annual max

Patient eligibility

Patient must enroll or activate (may permit HCPs to enroll on patient’s behalf for HCP-administered drugs)
Generally, must have commercial insurance (rarely, may permit uninsured patients to use)
May never be used with government insurance

How to sign up

Cards may be downloadable digital cards or hard copies
Some pharmacos offer debit cards with pre-loaded copay benefit
Typically, available through multiple channels (e.g., rep to HCP to patient; pharmacy to patient; patient via website, Hub live agent, or copay vendor (live agent or IVR); patient and HCP via Hub enrollment form)
Some HCP-administered product programs permit HCPs to enroll on a patient’s behalf through via Hub form

patient education

Cinryze patient education

Getting started on Cinryze

BRAND PAGEInstructions For Use: HAE

ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

To share resource; ask patient to:

1.Pull out phone

2.Open camera

3.Scan QR code with camera

4.Tap link

Patient toolkit

PDFDoctor Discussion Guide

ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

PDFHAE Family Tree Worksheet

ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

PDFHAE Attack Plan Letter

ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

PDFCaring for Someone with HAE Brochure

ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

PDFPower of Prevention Brochure

ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

Sign-Up for Information about HAE

ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

BRAND PAGEAbout Cinryze

ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

Effectiveness of Cinryze

ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

OTHERReceiving Cinryze

ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

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Other resources

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Cinryze FAQs

How is the dosage of Cinryze?Cinryze is available in 1 dosages, including 500 unt Injection

What does Cinryze treat?Cinryze treats Hereditary Angioedemas

What is Cinryze made of?Cinryze contains C1 esterase inhibitor which is a Human C1 Esterase Inhibitor

How Is Cinryze Administered?Cinryze is administered as a Injectable

What Are The Cinryze Mechanism Of Action?Cinryze mechanism of action is Kallikrein Inhibitors

FAQ Data Source

Cinryze

Dosage & administration

drug label

Cinryze prescribing information

prior authorization

Cinryze prior authorization resources

Most recent Cinryze prior authorization forms

Benefits investigation

financial assistance

Cinryze financial assistance options

Co-pay savings program

patient education

Cinryze patient education

Getting started on Cinryze

Patient toolkit

Other resources

people also ask

Cinryze FAQs