C1 esterase inhibitor (human) 500 UNT Injection [Cinryze]
NO BLACK BOX WARNING
Dosage & administration
For Intravenous Use Only
Routine Prophylaxis Dosing
Adults and adolescents (12 years old and above)
Indication
Dose
Infusion rate
* Doses up to 2,000 IU (not exceeding 80 IU/kg) every 3 or 4 days may be considered based on individual patient response.
Routine prophylaxis against HAE attacks
1,000 IU Intravenous every 3 or 4 days *
1 mL/min (10 min)
Children (6 to 11 years old)
Indication
Dose
Infusion rate
* Doses up to 1,000 IU every 3 or 4 days may be considered based on individual patient response.
Routine prophylaxis against HAE attacks
500 IU Intravenous every 3 or 4 days *
1 mL/min (5 min)
drug label
Cinryze prescribing information
Have more Cinryze questions?
Submit MSL Request
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Your request will be referred to the appropriate ViroPharma Biologics LLC medical professional, such as a Cinryze pharmaceutical rep; Medical Science Liaison (MSL) or medical affairs.
Need to report a Cinryze issue?
ONLINE FORMReport adverse event
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You can report a Cinryze adverse event on MedWatch, the FDA's medical product safety reporting program for health professionals, patients and consumers.
prior authorization
Cinryze Prior authorization resources
Complete Letter of Medical Necessity
NOT PROVIDED BY BRANDCoverage Authorization Request
NOT PROVIDED BY BRANDCoverage Authorization Appeals
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If available, these templates are provided by the brand to help you navigate insurance, especially with newer drugs.
Benefits investigation
One Path Enrollment Form
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Benefits investigations are conducted to determine whether a therapy is covered under a patient's insurance, if a prior authorization is required, and which specialty pharmacies are preferred.
Reimbursement help (FRM)
NOT PROVIDED BY BRANDReimbursement help (FRM) resources
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Some brands offer a field reimbursement manager who will work with your clinical staff and preferred pharmacy to help make sure patients don't fall through the cracks.
financial assistance
Cinryze Financial assistance options
Co-pay savings program
commercial only
One Path Enrollment Form
Enroll in Patient Savings Program
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Overview
Reduce patient OOP costs for drug (and occasionally for drug administration/infusion costs or drug-related test costs)
Patient benefit
A portion (or all) of patient OOP (deductible, copay), typically up to monthly and/or annual max
Patient eligibility
Patient must enroll or activate (may permit HCPs to enroll on patient’s behalf for HCP-administered drugs)
Generally, must have commercial insurance (rarely, may permit uninsured patients to use)
May never be used with government insurance
How to sign up
Cards may be downloadable digital cards or hard copies
Some pharmacos offer debit cards with pre-loaded copay benefit
Typically, available through multiple channels (e.g., rep to HCP to patient; pharmacy to patient; patient via website, Hub live agent, or copay vendor (live agent or IVR); patient and HCP via Hub enrollment form)
Some HCP-administered product programs permit HCPs to enroll on a patient’s behalf through via Hub form
Bridge program
commercial only
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Overview
Provide patient immediate access to therapy during an insurance delay (typically new starts; some may cover change in insurance)
Limited time/ fill (typically 7-30 days; some may offer additional fill for continued delay up to certain limit)
Patient benefit
100% free (outside of insurance)
Patient eligibility
HCP must enroll patient
May be limited to commercially insured patients (i.e., no government beneficiaries); some programs may allow government beneficiaries
How to sign up
Typically HCP assisted enrollment (via form)
Foundation programs
under insured
no insurance
goverment insurance
65+
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Overview
Charitable 501(c)(3) organizations provide direct cost-sharing and other support (e.g., travel, counseling) through disease-state funds to indigent patients on first-come first-served basis
These organizations may receive financial contributions from drug manaufacturers for particular disease-state funds that cannot provide funds directly to patients - the foundation must be independent/unaligned
Patient benefit
Patients apply for grants that cover a portion (or all) of their out-of-pocket costs (deductibles and co-pays) until the grant is exhausted
Patient eligibility
Patients must apply and meet eligibility criteria including income level (typically a multiple of federal poverty line), specific diagnosis, insurance status, etc.
How to sign up
Patients submit proof of out-of-pocket drug costs to charities for reimbursement
patient education
Cinryze Patient education
Getting started on Cinryze
Instructions For Use: HAE
ASK PATIENT TO: Open Camera on Phone Scan QR Code & Tap Link
Patient toolkit
Doctor Discussion Guide
ASK PATIENT TO: Open Camera on Phone Scan QR Code & Tap Link
HAE Family Tree Worksheet
ASK PATIENT TO: Open Camera on Phone Scan QR Code & Tap Link
HAE Attack Plan Letter
ASK PATIENT TO: Open Camera on Phone Scan QR Code & Tap Link
Caring for Someone with HAE Brochure
ASK PATIENT TO: Open Camera on Phone Scan QR Code & Tap Link
Power of Prevention Brochure
ASK PATIENT TO: Open Camera on Phone Scan QR Code & Tap Link
Sign-Up for Information about HAE
ASK PATIENT TO: Open Camera on Phone Scan QR Code & Tap Link
About Cinryze
ASK PATIENT TO: Open Camera on Phone Scan QR Code & Tap Link
Effectiveness of Cinryze
ASK PATIENT TO: Open Camera on Phone Scan QR Code & Tap Link
Receiving Cinryze
ASK PATIENT TO: Open Camera on Phone Scan QR Code & Tap Link
Learn More
Other resources brands publish to help support patients and caregivers.
people also ask
Cinryze FAQs
FAQ Data Source
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Please note:
Access to a Field Reimbursement Manager (FRM) or Medical Science Liaison (MSL) varies by brand and may require talking with your rep first.
Samples are provided at the discretion of the brand.
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