Dosage & Administration

For subcutaneous use only

Before switching to CUTAQUIG, obtain the patient’s serum IgG trough level to guide subsequent dose adjustments.

Dose

Switching from Immune Globulin Intravenous (IGIV) to CUTAQUIG: calculate the dosing by using a dose conversion factor (1.30); Switching from other Immune Globulin Subcutaneous (IGSC): dosing should be the same as for previous IGSC.

Weekly: Start CUTAQUIG one week after last IGIV infusion

Initial weekly dose = Previous IGIV dose (in grams) x 1.30

No. of weeks between IGIV doses

Every other week: Start CUTAQUIG 1 or 2 weeks after the last IGIV dosing or 1 week after the last IGSC administration. Infuse twice the calculated weekly dose.

More frequent than weekly (2-7 times a week): start CUTAQUIG 1 week after last IGIV or IGSC administration. Divide the calculated weekly dose by the desired number of infusions per week.

Adjust dosing according to patient’s pharmacokinetics and clinical response. (see Dose Adjustment)

Administration :

Administer at regular interval from daily up to every other week. Infusion rate and infusion volume per site may gradually be increased every 2-4 weeks as tolerated by patients.

Infusion sites: up to 6 infusion sites simultaneously, with at least 2 inches between sites. Rotate sites for each administration.

Refer to section 2.3 of full prescribing information for infusion parameters.

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