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Check Drug InteractionsDosage & Administration
Indication | Starting Dose | Target Dose | Maximum Dose |
MDD (2.2) | 37.5-75 mg/day | 75 mg/day | 225 mg/day |
GAD (2.3) | 37.5-75 mg/day | 75 mg/day | 225 mg/day |
SAD (2.4) | 75 mg/day | 75 mg/day | 75 mg/day |
PD (2.5) | 37.5 mg/day | 75 mg/day | 225 mg/day |
Effexor XR Prescribing Information
Antidepressants increased the risk of suicidal thoughts and behavior in pediatric and young adult patients in short-term studies. Closely monitor all antidepressant-treated patients for clinical worsening, and emergence of suicidal thoughts and behaviors
[see Warnings and Precautions (5.1)]
. Effexor XR is not approved for use in pediatric patients [see Use in Specific Populations (8.4)]
.
Warnings and Precautions 8/2023
Effexor XR is indicated in adults for the treatment of:
• Major Depressive Disorder (MDD)[see Clinical Studies (14.1)]• Generalized Anxiety Disorder (GAD)[see Clinical Studies (14.2)]• Social Anxiety Disorder (SAD)[see Clinical Studies (14.3)]• Panic Disorder (PD)[see Clinical Studies (14.4)]
Indication | Starting Dose | Target Dose | Maximum Dose |
MDD (2.2) | 37.5-75 mg/day | 75 mg/day | 225 mg/day |
GAD (2.3) | 37.5-75 mg/day | 75 mg/day | 225 mg/day |
SAD (2.4) | 75 mg/day | 75 mg/day | 75 mg/day |
PD (2.5) | 37.5 mg/day | 75 mg/day | 225 mg/day |
• Take once daily with food. Capsules should be taken whole; do not divide, crush, chew, or dissolve .• When discontinuing treatment, reduce the dose gradually .• Renal impairment: reduce the total daily dose by 25% to 50% in patients with renal impairment. Reduce the total daily dose by 50% or more in patients undergoing dialysis or with severe renal impairment .• Hepatic impairment: reduce the daily dose by 50% in patients with mild to moderate hepatic impairment. In patients with severe hepatic impairment or hepatic cirrhosis, it may be necessary to reduce the dose by more than 50% .
Effexor XR® is available in the following strengths:
• 37.5 mg extended-release capsule: grey cap and peach body with “W” and “Effexor XR” on the cap and “37.5” on the body• 75 mg extended-release capsule: peach cap and body with “W” and “Effexor XR” on the cap and “75” on the body• 150 mg extended-release capsule: dark orange cap and body with “W” and “Effexor XR” on the cap and “150” on the body
Pregnancy:
Third trimester use may increase risk for symptoms of poor neonatal adaptation (respiratory distress, temperature instability, feeding difficulty, hypotonia, tremor, irritability) in the neonate . We receive information directly from the FDA and PrescriberPoint is updated as frequently as changes are made available