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Hizentra

(immunoglobulin G)

10 ML immunoglobulin G, human 200 MG/ML Injection [Hizentra]10 ML immunoglobulin G, human 200 MG/ML Prefilled Syringe [Hizentra]

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BOXED WARNING

Dosage & administration

For subcutaneous infusion only.

Dose

Before switching to HIZENTRA, obtain the patient's serum IgG trough level to guide subsequent dose adjustments.

* Weekly: Start HIZENTRA 1 week after last Immune Globulin Intravenous (Human) (IGIV) infusion.

Initial weekly dose =	Previous IGIV dose (in grams) × 1.37
	No. of weeks between IGIV doses

* Biweekly (every 2 weeks): Start HIZENTRA 1 or 2 weeks after the last IGIV infusion or 1 week after the last weekly IGSC infusion. Administer twice the calculated weekly dose.
* Frequent dosing (2 to 7 times per week): Start HIZENTRA 1 week after the last IGIV or IGSC infusion. Divide the calculated weekly dose by the desired number of times per week.
* Adjust the dose based on clinical response and serum IgG trough levels.

CIDP

* Initiate therapy with HIZENTRA 1 week after the last IGIV infusion.
* Recommended subcutaneous dose is 0.2 g/kg (1 mL/kg) body weight per week.
* In the clinical study after transitioning from IGIV to HIZENTRA, a dose of 0.4 g/kg (2 mL/kg) body weight per week was also safe and effective to prevent CIDP relapse.

* If CIDP symptoms worsen, on 0.2 g/kg (1 mL/kg) body weight per week, consider increasing the HIZENTRA dose from 0.2 g/kg to 0.4 g/kg body weight per week.
* If CIDP symptoms worsen on 0.4 g/kg body weight per week, consider re-initiating therapy with IGIV, while discontinuing HIZENTRA.

* Monitor patient's clinical response and adjust duration of therapy based on patient need.

Administration

* PI: Administer at regular intervals from daily up to every 2 weeks.
* CIDP: Administer weekly.
* Infusion sites – Up to 8 infusion sites are allowed simultaneously, with at least 2 inches between sites.

Administration in PI
Infusion Parameters *	1st Infusion	Subsequent Infusions
* As tolerated
Volume (mL/site)	≤15	≤25
Rate (mL/hr/site)	≤15	≤25

Administration in CIDP
Infusion Parameters *	1st Infusion	Subsequent Infusions
* As tolerated
Volume (mL/site)	≤20	≤50
Rate (mL/hr/site)	≤20	≤50

drug label

Hizentra prescribing information

Contact Medical Science Liaison Report Adverse Event

prior authorization

Hizentra prior authorization resources

Most recent Hizentra prior authorization forms

View By Payer

Verified: Nov 09, 2023Kaiser Foundation Health Plan - Hizentra Prior Authorization Form Washington

Verified: Dec 01, 2023Blue Cross Blue Shield of Michigan - FEP Immune Globulin Replacement Therapy SC Prior Authorization Form (Medical Benefit)

Verified: Nov 27, 2023Cigna - Intravenous Immune Globulin (IVIG) -SCIG Prior Authorization Form

Verified: Nov 25, 2023Blue Cross Blue Shield of Michigan - IVIG Prior Authorization Form (Medical Benefit)

Verified: Nov 20, 2023Aetna - Hizentra Prior Authorization Form

Verified: Nov 19, 2023Aetna - Medicare Part B Immunoglobulin Prior Authorization Form

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Benefits investigation

Hizentra Prescription Referral Form

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Reimbursement help (FRM)

Receive Assistance from an FRM Regarding Reimbursement Information

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financial assistance

Hizentra financial assistance options

Co-pay savings program

commercial only

Hizentra Prescription Referral Form

Enroll in Patient Savings Program

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Overview

Reduce patient OOP costs for drug (and occasionally for drug administration/infusion costs or drug-related test costs)

Patient benefit

A portion (or all) of patient OOP (deductible, copay), typically up to monthly and/or annual max

Patient eligibility

Patient must enroll or activate (may permit HCPs to enroll on patient’s behalf for HCP-administered drugs)
Generally, must have commercial insurance (rarely, may permit uninsured patients to use)
May never be used with government insurance

How to sign up

Cards may be downloadable digital cards or hard copies
Some pharmacos offer debit cards with pre-loaded copay benefit
Typically, available through multiple channels (e.g., rep to HCP to patient; pharmacy to patient; patient via website, Hub live agent, or copay vendor (live agent or IVR); patient and HCP via Hub enrollment form)
Some HCP-administered product programs permit HCPs to enroll on a patient’s behalf through via Hub form

Bridge program

commercial only

Enroll in Bridge Program (Protection if you lose insurance)

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Overview

Provide patient immediate access to therapy during an insurance delay (typically new starts; some may cover change in insurance)
Limited time/ fill (typically 7-30 days; some may offer additional fill for continued delay up to certain limit)

Patient benefit

100% free (outside of insurance)

Patient eligibility

HCP must enroll patient
May be limited to commercially insured patients (i.e., no government beneficiaries); some programs may allow government beneficiaries

How to sign up

Typically HCP assisted enrollment (via form)

patient education

Hizentra patient education

Getting started on Hizentra

Instructions For Use: Primary Immune Deficiency (PI)

ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

Instructions For Use: Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

To share resource; ask patient to:

1.Pull out phone

2.Open camera

3.Scan QR code with camera

4.Tap link

Patient toolkit

About Hizentra: Primary Immune Deficiency (PI)

ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

About Hizentra: Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

Side Effects: Primary Immune Deficiency (PI)

ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

Side Effects: Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

View How to Take Hizentra: Primary Immune Deficiency (PI)

ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

View How to Take Hizentra: Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

Patient Stories: Primary Immune Deficiency (PI)

ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

Patient Stories: Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

Patient Brochure: Primary Immune Deficiency (PI)

ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

Patient Brochure: Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

Doctor Discussion Guide: Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

Doctor Discussion Guide: Primary Immune Deficiency (PI)

ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

Learn More

Other resources

App Download

ASK PATIENT TO:
Open Camera on Phone
Scan QR Code & Tap Link

Learn More

Hizentra FAQs

How is the dosage of Hizentra?Hizentra is available in 7 dosages, including 200 mg/ml Injection 10 ml, 200 mg/ml Injection 20 ml, 200 mg/ml Injection 5 ml, 200 mg/ml Injection 50 ml, 200 mg/ml Prefilled Syringe 10 ml, 200 mg/ml Prefilled Syringe 20 ml and 200 mg/ml Prefilled Syringe 5 ml

What does Hizentra treat?Hizentra treats Immunologic Deficiency Syndromes

What is Hizentra made of?Hizentra contains immunoglobulin G which is a Human Immunoglobulin G

How Is Hizentra Administered?Hizentra is administered as a Injectable

What Are The Hizentra Mechanism Of Action?Hizentra mechanism of action is Antigen Neutralization

FAQ Data Source

Hizentra

Dosage & administration

drug label

Hizentra prescribing information

prior authorization

Hizentra prior authorization resources

Most recent Hizentra prior authorization forms

Benefits investigation

Reimbursement help (FRM)

financial assistance

Hizentra financial assistance options

Co-pay savings program

Bridge program

patient education

Hizentra patient education

Getting started on Hizentra

Patient toolkit

Other resources

people also ask

Hizentra FAQs