What is the dosage of Bivigam?

Bivigam is available in 15 dosages, including 100 mg/ml Injection 100 ml, 100 mg/ml Injection 200 ml, 100 mg/ml Injection 25 ml, 100 mg/ml Injection 300 ml, 100 mg/ml Injection 50 ml, 160 unt/ml Injection 1.25 ml, 160 unt/ml Injection 10 ml, 160 unt/ml Injection 2.5 ml, 2,400 unt/15ml Injection 15 ml, 800 unt/5ml Injection 5 ml, mixed Pack, mixed Pack, mixed Pack, mixed Pack and mixed Pack

What does Bivigam treat?

Bivigam treats Extravasation of Diagnostic and Therapeutic Materials and Immunologic Deficiency Syndromes

What is Bivigam made of?

Bivigam contains hyaluronidase and immunoglobulin G which is a Endoglycosidase

How is Bivigam administered?

Bivigam is administered as a Injectable or Pack

What is Bivigam mechanism of action?

Bivigam mechanism of action is Antigen Neutralization

Dosage & Administration Drug label Prior authorization Financial assistance

Patient education

Bivigam

(hyaluronidase, immunoglobulin G)

100 ML immunoglobulin G, human 100 MG/ML Injection [Bivigam]100 ML immunoglobulin G, human 100 MG/ML Injection [Flebogamma]

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BLACK BOX WARNING

Dosage & administration

For subcutaneous use only.

Initial Treatment Interval/Dosage Ramp-Up Schedule
Week	Infusion Number	Dose Interval	Example for 30 grams per 4 weeks
1	1st infusion	1-week-dose	7.5 grams
2	2nd infusion	2-week-dose	15 grams
3	No infusion
4	3rd infusion	3-week-dose	22.5 grams
5	No infusion
6	No infusion
7	4th infusion (if required)	4-week-dose	30 grams

Naïve to Immune Globulin Subcutaneous (Human) [IGSC] treatment or switching from IGSC: 300 to 600 mg/kg at 3 to 4-week intervals, after initial ramp-up.

Switching from Immune Globulin Intravenous (Human) [IGIV] treatment: Use same dose and frequency as previous intravenous treatment after the initial ramp-up.

drug label

Bivigam prescribing information

Have more Bivigam questions?

Submit MSL Request

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Need to report a Bivigam issue?

ONLINE FORMReport adverse event

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prior authorization

Bivigam Prior authorization resources

NOT PROVIDED BY BRANDComplete Letter of Medical Necessity

NOT PROVIDED BY BRANDCoverage Authorization Request

NOT PROVIDED BY BRANDCoverage Authorization Appeals

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Benefits investigation

Hyqvia One Path Start Form

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Reimbursement help (FRM)

NOT PROVIDED BY BRANDReimbursement help (FRM) resources

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financial assistance

Bivigam Financial assistance options

Co-pay savings program

commercial only

Hyqvia One Path Start Form

Enroll in Patient Savings Program

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Overview

Reduce patient OOP costs for drug (and occasionally for drug administration/infusion costs or drug-related test costs)

Patient benefit

A portion (or all) of patient OOP (deductible, copay), typically up to monthly and/or annual max

Patient eligibility

Patient must enroll or activate (may permit HCPs to enroll on patient’s behalf for HCP-administered drugs)
Generally, must have commercial insurance (rarely, may permit uninsured patients to use)
May never be used with government insurance

How to sign up

Cards may be downloadable digital cards or hard copies
Some pharmacos offer debit cards with pre-loaded copay benefit
Typically, available through multiple channels (e.g., rep to HCP to patient; pharmacy to patient; patient via website, Hub live agent, or copay vendor (live agent or IVR); patient and HCP via Hub enrollment form)
Some HCP-administered product programs permit HCPs to enroll on a patient’s behalf through via Hub form

Bridge program

commercial only

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Overview

Provide patient immediate access to therapy during an insurance delay (typically new starts; some may cover change in insurance)
Limited time/ fill (typically 7-30 days; some may offer additional fill for continued delay up to certain limit)

Patient benefit

100% free (outside of insurance)

Patient eligibility

HCP must enroll patient
May be limited to commercially insured patients (i.e., no government beneficiaries); some programs may allow government beneficiaries

How to sign up

Typically HCP assisted enrollment (via form)

Foundation programs

under insured

no insurance

goverment insurance

65+

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Overview

Charitable 501(c)(3) organizations provide direct cost-sharing and other support (e.g., travel, counseling) through disease-state funds to indigent patients on first-come first-served basis
These organizations may receive financial contributions from drug manaufacturers for particular disease-state funds that cannot provide funds directly to patients - the foundation must be independent/unaligned

Patient benefit

Patients apply for grants that cover a portion (or all) of their out-of-pocket costs (deductibles and co-pays) until the grant is exhausted

Patient eligibility

Patients must apply and meet eligibility criteria including income level (typically a multiple of federal poverty line), specific diagnosis, insurance status, etc.

How to sign up

Patients submit proof of out-of-pocket drug costs to charities for reimbursement