Biguanide

Dipeptidyl Peptidase 4 Inhibitor

Dipeptidyl Peptidase 4 Inhibitors

Type 2 Diabetes Mellitus

<section class="Section" data-sectioncode="34089-3"><a name="S11"></a><a name="section-10"></a><h1>11 DESCRIPTION</h1>JENTADUETO tablets for oral use contain: linagliptin and metformin hydrochloride.<div class="Section" data-sectioncode="42229-5"><a name="section-10.1"></a>LinagliptinLinagliptin is an inhibitor of the dipeptidyl peptidase-4 (DPP-4) enzyme.The chemical name of linagliptin is 1H-Purine-2,6-dione, 8-[(3R)-3-amino-1-piperidinyl]-7-(2-butyn-1-yl)-3,7-dihydro-3-methyl-1-[(4-methyl-2-quinazolinyl)methyl]-The molecular formula is C25H28N8O2 and the molecular weight is 472.54 g/mol. The structural formula is:<img alt="Chemical Structure" src="jentadueto-01.jpg"/>Linagliptin is a white to yellowish, not or only slightly hygroscopic solid substance. It is very slightly soluble in water (0.9 mg/mL). Linagliptin is soluble in methanol (ca. 60 mg/mL), sparingly soluble in ethanol (ca. 10 mg/mL), very slightly soluble in isopropanol (&lt;1 mg/mL), and very slightly soluble in acetone (ca. 1 mg/mL).</div><div class="Section" data-sectioncode="42229-5"><a name="section-10.2"></a>Metformin HydrochlorideMetformin hydrochloride (N,N-dimethylimidodicarbonimidic diamide hydrochloride) is a biguanide. Metformin hydrochloride is a white to off-white crystalline compound with a molecular formula of C4H11N5∙HCl and a molecular weight of 165.63 g/mol. Metformin hydrochloride is freely soluble in water and is practically insoluble in acetone, ether, and chloroform. The pKa of metformin is 12.4. The pH of a 1% aqueous solution of metformin hydrochloride is 6.68. The structural formula is:<img alt="Chemical Structure" src="jentadueto-02.jpg"/></div><div class="Section" data-sectioncode="42229-5"><a name="section-10.3"></a>JENTADUETOJENTADUETO is available for oral administration as tablets containing:<ul class="Disc"><li>2.5 mg linagliptin and 389.93 mg of metformin equivalent to 500 mg metformin hydrochloride (JENTADUETO 2.5 mg/500 mg)</li><li>2.5 mg linagliptin and 662.88 mg of metformin equivalent to 850 mg metformin hydrochloride (JENTADUETO 2.5 mg/850 mg)</li><li>2.5 mg linagliptin and 779.86 mg of metformin equivalent to 1000 mg metformin hydrochloride (JENTADUETO 2.5 mg/1000 mg)</li></ul>Each film-coated tablet of JENTADUETO contains the following inactive ingredients: arginine, corn starch, copovidone, colloidal silicon dioxide, magnesium stearate, titanium dioxide, propylene glycol, hypromellose, talc, yellow ferric oxide (2.5 mg/500 mg; 2.5 mg/850 mg) and/or red ferric oxide (2.5 mg/850 mg; 2.5 mg/1000 mg).</div></section>

Jentadueto

linagliptin

linagliptin / metformin

linagliptin 2.5 MG / metformin hydrochloride 1000 MG Oral Tablet

linagliptin 2.5 MG / metformin hydrochloride 1000 MG Oral Tablet [Jentadueto]

linagliptin 2.5 MG / metformin hydrochloride 500 MG Oral Tablet

linagliptin 2.5 MG / metformin hydrochloride 500 MG Oral Tablet [Jentadueto]

linagliptin 2.5 MG / metformin hydrochloride 850 MG Oral Tablet

linagliptin 2.5 MG / metformin hydrochloride 850 MG Oral Tablet [Jentadueto]

metformin

Report Adverse Event 

Prescribing Information

Medication Guide 

Submit MSL Request 

Pharmacy List 

Formulary Information

Coverage Authorization Request 

Coverage Authorization Appeals 

Enroll in Patient Savings Program 

BI Cares Foundation Patient Assistance Program Application

Efficacy

Safety Profile

Dosing 

Other HCP Resources

Blood Sugar Tracker 

About Jentadueto

Taking Jentadueto

Doctor Discussion Guide 

Instructions For Use: Type 2 Diabetes 

Jentadueto

Dosage & administration

drug label

Jentadueto prescribing information

Have more Jentadueto questions?

Need to report a Jentadueto issue?

people also ask

Jentadueto FAQs

Can't find what you're looking for?