What is the dosage of Kombiglyze?

Kombiglyze is available in 3 dosages, including 1,000-2.5 mg 24 HR XR Tab, 500-5 mg 24 HR XR Tab and 1,000-5 mg 24 HR XR Tab

What does Kombiglyze treat?

Kombiglyze treats Diabetes Mellitus, Type 2

What is Kombiglyze made of?

Kombiglyze contains metformin / saxagliptin which is a Biguanide

How is Kombiglyze administered?

Kombiglyze is administered as a Oral Pill

Kombiglyze XR Prescribing & Dosing Schedule

Last Update: Oct, 13 2024

Kombiglyze XR(metformin hydrochloride)

kombiglyze XR 2.5 MG / 1000 MG 24HR Extended Release Oral Tablet

BOXED WARNING

Dosage & Administration

* Administer once daily with the evening meal. (2.1)
* Individualize the starting dose based on the patient’s current regimen then adjust the dosage based on effectiveness and tolerability. (2.1)
* Do not exceed a daily dosage of 5 mg saxagliptin/2000 mg metformin HCl extended-release. (2.1)
* Swallow whole. Never crush, cut, or chew. (2.1)
* Limit the saxagliptin dosage to 2.5 mg daily for patients also taking strong cytochrome P450 3A4/5 inhibitors (e.g., ketoconazole). (2.2, 7.1)
* Assess renal function prior to initiation of KOMBIGLYZE XR and periodically thereafter. (2.3)
* Do not use in patients with eGFR below 30 mL/min/1.73 m2.
* Initiation is not recommended in patients with eGFR between 30 - 45 mL/min/1.73 m2.
* Assess risk/benefit of continuing if eGFR falls below 45 mL/min/1.73 m2.
* Limit the saxagliptin component to 2.5 mg daily if eGFR is less than 45 mL/min/1.73 m2.
* Discontinue if eGFR falls below 30 mL/min/1.73 m2.

* KOMBIGLYZE XR may need to be discontinued at time of, or prior to, iodinated contrast imaging procedures. (2.4)

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Kombiglyze XR Prescribing Information

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Kombiglyze XR Prior Authorization Resources

Most recent state uniform prior authorization forms

Verified: Sep 24, 2024Arizona - Uniform Prior Authorization Form

Verified: Sep 24, 2024Colorado - Uniform Prior Authorization Form

Verified: Sep 24, 2024Hawaii - Uniform Prior Authorization Form

Verified: Sep 24, 2024Illinois - Uniform Prior Authorization Form

Verified: Sep 24, 2024Indiana - Uniform Prior Authorization Form

Verified: Sep 24, 2024Louisiana - Uniform Prior Authorization Form

Verified: Sep 24, 2024Minnesota - Uniform Prior Authorization Form

Verified: Sep 24, 2024New Hampshire - Uniform Prior Authorization Form

Verified: Sep 24, 2024New Mexico - Uniform Prior Authorization Form

Verified: Sep 24, 2024Oregon - Uniform Prior Authorization Form

Verified: Sep 24, 2024Texas - Uniform Prior Authorization Form

Verified: Oct 05, 2024Washington - Uniform Prior Authorization Form

Verified: Oct 05, 2024Wisconsin - Uniform Prior Authorization Form

Reimbursement help (FRM)

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Kombiglyze XR Financial Assistance Options

Copay savings program

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Rebate Form - Mail Order Patients

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Overview

Reduce patient OOP costs for drug (and occasionally for drug administration/infusion costs or drug-related test costs)

Patient benefit

A portion (or all) of patient OOP (deductible, copay), typically up to monthly and/or annual max

Patient eligibility

Patient must enroll or activate (may permit HCPs to enroll on patient’s behalf for HCP-administered drugs)
Generally, must have commercial insurance (rarely, may permit uninsured patients to use)
May never be used with government insurance

How to sign up

Cards may be downloadable digital cards or hard copies
Some pharmacos offer debit cards with pre-loaded copay benefit
Typically, available through multiple channels (e.g., rep to HCP to patient; pharmacy to patient; patient via website, Hub live agent, or copay vendor (live agent or IVR); patient and HCP via Hub enrollment form)
Some HCP-administered product programs permit HCPs to enroll on a patient’s behalf through via Hub form