Octagam 10%(immunoglobulin G, human)
octagam 10 % in 100 ML Injection
BOXED WARNING

Dosage & Administration

For intravenous use only.

IndicationDoseInitial Infusion rateMaintenance Infusion Rate (if tolerated)
Chronic ITP2 g/kg divided in equal doses given over 2 consecutive days1.0 mg/kg/min(0.01 mL/kg/min)Up to 12.0 mg/kg/min(Up to 0.12 mL/kg/min)
Dermato-myositis2 g/kg divided in equal doses given over 2-5 consecutive days every 4 weeks1.0 mg/kg/min(0.01 mL/kg/min)Up to 4.0 mg/kg/min(Up to 0.04 mL/kg/min)

•Patients with dermatomyositis are at increased risk for thromboembolic Events; monitor carefully and do not exceed an infusion rate of 0.04 ml/kg/min.

•Ensure that patients with pre-existing renal insufficiency are not volume depleted; discontinue Octagam 10% if renal function deteriorates .

•For patients at risk of renal dysfunction or thrombotic events, administer Octagam 10% at the minimum infusion rate practicable .

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