Janus Kinase Inhibitors

Janus Kinase Inhibitor

Arthritis, Rheumatoid

<section class="Section" data-sectioncode="34089-3"><a name="s95"></a><a name="section-9"></a><p></p><h1>11 DESCRIPTION</h1><p class="First">OLUMIANT (baricitinib) is a Janus kinase (JAK) inhibitor with the chemical name {1-(ethylsulfonyl)-3-[4-(7<span class="Italics">H</span>-pyrrolo[2,3-<span class="Italics">d</span>]pyrimidin-4-yl)-1<span class="Italics">H</span>-pyrazol-1-yl]azetidin-3-yl}acetonitrile. Baricitinib has an empirical formula of C<span class="Sub">16</span>H<span class="Sub">17</span>N<span class="Sub">7</span>O<span class="Sub">2</span>S and a molecular weight of 371.42. Baricitinib has the following structural formula:</p><div class="Figure"><a name="f01"></a><img alt="Structural Formula
" src="olumiant-uspi-chem-v1.jpg"/></div><p>OLUMIANT tablets contain a recessed area on each face of the tablet surface and are available for oral administration as debossed, film-coated tablets. The 1 mg tablet is very light pink, round, debossed with “Lilly” on one side and “1” on the other. The 2 mg tablet is light pink, oblong, debossed with “Lilly” on one side and “2” on the other. The 4 mg tablet is medium pink, round, debossed with “Lilly” on one side and “4” on the other.</p><p>Each tablet contains 1, 2, or 4 mg of baricitinib and the following inactive ingredients: croscarmellose sodium, ferric oxide, lecithin (soya), magnesium stearate, mannitol, microcrystalline cellulose, polyethylene glycol, polyvinyl alcohol, talc and titanium dioxide.</p></section>

Olumiant | UKansas Health System Specialty Pharmacy

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