Orkambi Prescribing & Dosing Schedule

Q: What is the dosage of ORKAMBI?

ORKAMBI is available in 5 dosages, including 125-100 mg Granules, 125-100 mg Tab, 125-200 mg Tab, 188-150 mg Granules and 94-75 mg Granules

Q: What is ORKAMBI made of?

ORKAMBI contains ivacaftor / lumacaftor which is a Cystic Fibrosis Transmembrane Conductance Regulator Potentiator

Q: How is ORKAMBI administered?

ORKAMBI is administered as a Oral Granules or Oral Pill

Q: What is ORKAMBI mechanism of action?

ORKAMBI mechanism of action is Chloride Channel Activation Potentiators, Cytochrome P450 2B6 Inducers, Cytochrome P450 2C19 Inducers, Cytochrome P450 2C8 Inducers, Cytochrome P450 2C8 Inhibitors, Cytochrome P450 2C9 Inducers, Cytochrome P450 2C9 Inhibitors, Cytochrome P450 3A Inducers, Cytochrome P450 3A Inhibitors, P-Glycoprotein Inducers or P-Glycoprotein Inhibitors

Dosage & Administration Drug label Prior authorization Pharmacy Financial assistance Patient education People also ask

Orkambi(ivacaftor / lumacaftor)

ORKAMBI 94 MG / 75 MG Oral Granules

NO BOXED WARNING

Dosage & Administration

Age Group	Weight	Dose	Administration
1 through 2 years	7 kg to < 9 kg	1 packet of lumacaftor 75 mg/ivacaftor 94 mg granules	Mixed with one teaspoon (5 mL) of soft food or liquid and administered orally every 12 hours with fat-containing food
	9 kg to < 14 kg	1 packet of lumacaftor 100 mg/ivacaftor 125 mg granules
	≥14 kg	1 packet of lumacaftor 150 mg/ivacaftor 188 mg granules
2 through 5 years	<14 kg	1 packet of lumacaftor 100 mg/ivacaftor 125 mg granules
2 through 5 years	≥14 kg	1 packet of lumacaftor 150 mg/ivacaftor 188 mg granules
6 through 11 years	-	2 tablets of lumacaftor 100 mg/ivacaftor 125 mg (lumacaftor 200 mg/ivacaftor 250 mg per dose)	Taken orally every 12 hours with fat-containing food
12 years and older	-	2 tablets of lumacaftor 200 mg/ivacaftor 125 mg (lumacaftor 400 mg/ivacaftor 250 mg per dose)	Taken orally every 12 hours with fat-containing food

* Reduce dosage in patients with moderate or severe hepatic impairment.
* When initiating ORKAMBI in patients taking strong CYP3A inhibitors, reduce ORKAMBI dosage for the first week of treatment.

drug label

Orkambi Prescribing Information

Contact Medical Science Liaison

Report Adverse Event

prior authorization

Orkambi Prior Authorization Resources

Most recent state uniform prior authorization forms

Verified: Jun 26, 2024Arizona - Uniform Prior Authorization Form

Verified: Jun 26, 2024Colorado - Uniform Prior Authorization Form

Verified: Jun 26, 2024Hawaii - Uniform Prior Authorization Form

Verified: Jul 26, 2024Illinois - Uniform Prior Authorization Form

Verified: Jun 26, 2024Indiana - Uniform Prior Authorization Form

Verified: Jun 26, 2024Louisiana - Uniform Prior Authorization Form

Verified: Jun 26, 2024Minnesota - Uniform Prior Authorization Form

Verified: Jun 26, 2024New Hampshire - Uniform Prior Authorization Form

Verified: Jun 26, 2024New Mexico - Uniform Prior Authorization Form

Verified: Jun 26, 2024Oregon - Uniform Prior Authorization Form

Verified: Jun 26, 2024Texas - Uniform Prior Authorization Form

Verified: Jul 07, 2024Washington - Uniform Prior Authorization Form

Verified: Jul 07, 2024Wisconsin - Uniform Prior Authorization Form

Benefits investigation

Vertex GPS Patient Enrollment Form

Vertex GPS Patient Enrollment Form - Spanish

Vertex GPS Patient Enrollment Form - Online

Reimbursement help (FRM)

Receive Assistance from an FRM Regarding Reimbursement Information

pharmacy

Orkambi Preferred Pharmacy

Pharmacy List

financial assistance

Orkambi Financial Assistance Options

Copay savings program

Enroll in Patient Savings Program

Vertex GPS Patient Enrollment Form

Vertex GPS Patient Enrollment Form - Spanish

Vertex GPS Patient Enrollment Form - Online

Learn More

Overview

Reduce patient OOP costs for drug (and occasionally for drug administration/infusion costs or drug-related test costs)

Patient benefit

A portion (or all) of patient OOP (deductible, copay), typically up to monthly and/or annual max

Patient eligibility

Patient must enroll or activate (may permit HCPs to enroll on patient’s behalf for HCP-administered drugs)
Generally, must have commercial insurance (rarely, may permit uninsured patients to use)
May never be used with government insurance

How to sign up

Cards may be downloadable digital cards or hard copies
Some pharmacos offer debit cards with pre-loaded copay benefit
Typically, available through multiple channels (e.g., rep to HCP to patient; pharmacy to patient; patient via website, Hub live agent, or copay vendor (live agent or IVR); patient and HCP via Hub enrollment form)
Some HCP-administered product programs permit HCPs to enroll on a patient’s behalf through via Hub form

patient education

Orkambi Patient Education

To share resource; ask patient to:

1.Pull out phone

2.Open camera

3.Scan QR code with camera

4.Tap link