GLP-1 Receptor Agonist

Glucagon-like Peptide-1 (GLP-1) Agonists

<section class="Section" data-sectioncode="34089-3"><a name="ID_1e1d2a6a-652d-4506-9690-a7191598edab"></a><a name="section-10"></a><p></p><h1>11 DESCRIPTION </h1><p class="First">OZEMPIC (semaglutide) injection, for subcutaneous use, contains semaglutide, a human GLP-1 receptor agonist (or GLP-1 analog). The peptide backbone is produced by yeast fermentation. The main protraction mechanism of semaglutide is albumin binding, facilitated by modification of position 26 lysine with a hydrophilic spacer and a C18 fatty di-acid. Furthermore, semaglutide is modified in position 8 to provide stabilization against degradation by the enzyme dipeptidyl-peptidase 4 (DPP-4). A minor modification was made in position 34 to ensure the attachment of only one fatty di-acid. The molecular formula is C<span class="Sub">187</span>H<span class="Sub">291</span>N<span class="Sub">45</span>O<span class="Sub">59</span> and the molecular weight is 4113.58 g/mol.</p><p>Structural formula:</p><div class="Figure"><a name="id-1317185040"></a><img alt="Structural Formula" src="image-01.jpg"/></div><p>OZEMPIC is a sterile, aqueous, clear, colorless solution. Each pre-filled pen contains a 1.5 mL or a 3 mL solution of OZEMPIC equivalent to 2 mg semaglutide, a 3 mL solution of OZEMPIC equivalent to 4 mg of semaglutide, or a 3 mL solution of OZEMPIC equivalent to 8 mg of semaglutide. Each 1 mL of OZEMPIC solution contains 0.68 mg, 1.34 mg or 2.68 mg of semaglutide and the following inactive ingredients: disodium phosphate dihydrate, 1.42 mg; propylene glycol, 14.0 mg; phenol, 5.50 mg; and water for injections. OZEMPIC has a pH of approximately 7.4. Hydrochloric acid or sodium hydroxide may be added to adjust pH.</p></section>

Ozempic

0.25 MG, 0.5 MG Dose 1.5 ML semaglutide 1.34 MG/ML Pen Injector

0.25 MG, 0.5 MG Dose 1.5 ML semaglutide 1.34 MG/ML Pen Injector [Ozempic]

0.25 MG, 0.5 MG Dose 3 ML semaglutide 0.68 MG/ML Pen Injector

0.25 MG, 0.5 MG Dose 3 ML semaglutide 0.68 MG/ML Pen Injector [Ozempic]

1 MG Dose 1.5 ML semaglutide 1.34 MG/ML Pen Injector

1 MG Dose 1.5 ML semaglutide 1.34 MG/ML Pen Injector [Ozempic]

3 ML semaglutide 1.34 MG/ML Pen Injector

3 ML semaglutide 1.34 MG/ML Pen Injector [Ozempic]

3 ML semaglutide 2.68 MG/ML Pen Injector

3 ML semaglutide 2.68 MG/ML Pen Injector [Ozempic]

semaglutide

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