DO NOT confuse micrograms (mcg) with International Units (IU) when calculating the dose. Miscalculations could result in overdose or underdose
Suppression of Rh Isoimmunization (IV or IM administration only)
| Indication | Timing | Dose * (1 mcg = 5 IU) |
|---|
| Rh-incompatible Pregnancy: | mcg | IU |
|---|
|
| Routine antepartum prophylaxis | Week 28-30 of pregnancy | 300 mcg | 1500 IU |
| Postpartum prophylaxis (required only if the newborn is Rh(D)-positive, or of unknown status) | Within 72 hours of birth | 300 mcg † | 1500 IU |
| Obstetric complications/invasive procedures | Within 72 hours of complication / procedure | 300 mcg † | 1500 IU |
| Excessive fetomaternal hemorrhage (>15 mL fetal RBCs) | Within 72 hours of complication | 300 mcg plus:
20 mcg per mL RhD-positive fetal RBCs in excess of 15 mL if excess transplacental bleeding is quantified, or
An additional 300 mcg if excess transplacental bleeding cannot be quantified | 1500 IU plus:
100 IU per mL RhD- positive fetal RBCs in excess of 15 mL if excess transplacental bleeding is quantified, or
An additional 1500 IU if excess transplacental bleeding cannot be quantified |
| Incompatible transfusions | Within 72 hours of exposure | 20 mcg per 2 mL transfused Rh(D)-positive whole blood or per 1 mL Rh(D)- positive RBCs | 100 IU per 2 mL transfused Rh(D)- positive whole blood or per 1 mL Rh(D)- positive RBCs |
Treatment of ITP (IV administration only)
| Dose (mcg) | Rate of administration |
|---|
| 50 mcg per kg body weight | 2 mL per 15 to 60 seconds |
