Rhophylac Prescribing & Dosing Schedule

Rhophylac(Rho(D) immune globulin, human)

Rhophylac 1500 UNT in 2 ML Prefilled Syringe

DO NOT confuse micrograms (mcg) with International Units (IU) when calculating the dose. Miscalculations could result in overdose or underdose

Suppression of Rh Isoimmunization (IV or IM administration only)

Indication	Timing	Dose * (1 mcg = 5 IU)
Rh-incompatible Pregnancy:		mcg	IU
* A 1500 IU (300 mcg) dose will suppress the immunizing potential of ≤15 mL of Rh(D)-positive RBCs.1* The dose must be increased if the patient is exposed to >15 mL of Rh(D)-positive RBCs; in this case, follow the dosing guidelines for excessive fetomaternal hemorrhage.
Routine antepartum prophylaxis	Week 28-30 of pregnancy	300 mcg	1500 IU
Postpartum prophylaxis (required only if the newborn is Rh(D)-positive, or of unknown status)	Within 72 hours of birth	300 mcg †	1500 IU
Obstetric complications/invasive procedures	Within 72 hours of complication / procedure	300 mcg †	1500 IU
Excessive fetomaternal hemorrhage (>15 mL fetal RBCs)	Within 72 hours of complication	300 mcg plus: 20 mcg per mL RhD-positive fetal RBCs in excess of 15 mL if excess transplacental bleeding is quantified, or An additional 300 mcg if excess transplacental bleeding cannot be quantified	1500 IU plus: 100 IU per mL RhD- positive fetal RBCs in excess of 15 mL if excess transplacental bleeding is quantified, or An additional 1500 IU if excess transplacental bleeding cannot be quantified
Incompatible transfusions	Within 72 hours of exposure	20 mcg per 2 mL transfused Rh(D)-positive whole blood or per 1 mL Rh(D)- positive RBCs	100 IU per 2 mL transfused Rh(D)- positive whole blood or per 1 mL Rh(D)- positive RBCs

Treatment of ITP (IV administration only)

Dose (mcg)	Rate of administration
50 mcg per kg body weight	2 mL per 15 to 60 seconds

Rhophylac Prescribing Information

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How is the dosage of Rhophylac?Rhophylac is available in 1 dosages, including 750 unt/ml Prefilled Syringe 2 ml

What does Rhophylac treat?Rhophylac treats Rh Isoimmunization and Idiopathic Thrombocytopenic Purpura

What is Rhophylac made of?Rhophylac contains Rho(D) immune globulin which is a Human Immunoglobulin G

How Is Rhophylac Administered?Rhophylac is administered as a Injectable

What Are The Rhophylac Mechanism Of Action?Rhophylac mechanism of action is Endogenous Antigen Neutralization

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