Soolantra

SOOLANTRA cream is indicated for the treatment of inflammatory lesions of rosacea.

Apply to the affected areas of the face once daily. Use a pea-size amount for each area of the face (forehead, chin, nose, each cheek) that is affected. Spread as a thin layer, avoiding the eyes and lips.




SOOLANTRA cream is not for oral, ophthalmic, or intravaginal use.

Cream, 1%.




Each gram of SOOLANTRA cream contains 10 mg of ivermectin in a white to pale yellow cream base. SOOLANTRA cream is supplied in tubes of 30 g, 45 g and 60 g.

In vitro studies have shown that SOOLANTRA cream, at therapeutic concentrations, neither inhibits nor induces cytochrome P450 (CYP450) enzymes.

SOOLANTRA (ivermectin) cream, 1% is a white to pale yellow hydrophilic cream intended for topical use. Each gram of SOOLANTRA cream contains 10 mg of ivermectin. 

Ivermectin is a semi-synthetic derivative isolated from the fermentation of Streptomyces avermitilis that belongs to the avermectin family of macrocyclic lactones.

Ivermectin is a mixture containing not less than 95.0% and not more than 102.0% of 5-O-demethyl-22,23-dihydroavermectin A
_1aplus 5-O-demethyl-25-de(1-methylpropyl)-25-(1-methylethyl)-22,23-dihydroavermectin A
_1a, generally referred to as 22,23-dihydroavermectin B
_1aand B
_1bor H
₂B
_1aand H
₂B
_1b, respectively; and the ratio (calculated by area percentage) of component H
₂B
_1a/(H
₂B
_1a+ H
₂B
_1b) is not less than 90.0%.


The respective empirical formulas of H
₂B
_1aand H
₂B
_1bare C
₄₈H
₇₄O
₁₄and C
₄₇H
₇₂O
₁₄with molecular weights of 875.10 and 861.07 respectively.

The structural formulas are:

Component H
₂B
_1a: R = C
₂H
₅, Component H
₂B
_1b: R = CH
₃.

SOOLANTRA cream contains the following inactive ingredients: carbomer copolymer type B, cetyl alcohol, citric acid monohydrate, dimethicone, edetate disodium, glycerin, isopropyl palmitate, methylparaben, oleyl alcohol, phenoxyethanol, polyoxyl 20 cetostearyl ether, propylene glycol, propylparaben, purified water, sodium hydroxide, sorbitan monostearate, and stearyl alcohol.