Summary of Initial Oral Dosage Recommendation and Observed Whole Blood Trough Concentrations ( 2.1, 2.2).
Patient Population | Recommended Tacrolimus Initial Oral Dosage (two divided doses every 12 hours) | Observed Whole Blood Trough Concentrations |
Adult Kidney transplant patients In combination with azathioprine |
0.2 mg/kg/day
|
month 1-3: 7-20 ng/mL
month 4-12: 5-15 ng/mL |
In combination with MMF/IL-2 receptor antagonist | 0.1 mg/kg/day | month 1-12: 4-11 ng/mL |
Adult Liver transplant | 0.10-0.15 mg/kg/day | month 1-12: 5-20 ng/mL |
Pediatric Liver transplant | 0.15-0.20 mg/kg/day | month 1-12: 5-20 ng/mL |
Adult Heart transplant | 0.075 mg/kg/day | month 1-3: 10-20 ng/mL month ≥4: 5-15 ng/mL |
•Careful and frequent monitoring of tacrolimus trough concentrations is recommended; Black patients may require higher doses in order to achieve comparable trough concentrations ( 2.1)•Hepatic/Renal impaired patients should receive doses at the lowest value of the recommended initial oral dosing range ( 2.3, 2.4)•Administer capsules consistently with or without food; do not drink grapefruit juice ( 2.5, 7.2)
