Tiglutik

Question 1

Are there studies on riluzole use during pregnancy?

Accepted Answer

No studies on riluzole in pregnant women are available. Case reports have been insufficient to determine the associated risk. The background risk for major birth defects and miscarriage in ALS patients and the general population is also unknown.

Question 2

What do animal studies indicate about riluzole's effects during pregnancy?

Accepted Answer

Oral administration of riluzole to pregnant animals resulted in decreased fetal growth, increased embryofetal mortality, and maternal toxicity at higher doses. These findings suggest potential developmental toxicity.

Question 3

Is there data on riluzole presence in breast milk and its effects on breastfeeding?

Accepted Answer

No data exists on riluzole presence in human milk or its effects on breastfed infants. However, riluzole or its metabolites have been detected in the milk of lactating rats. Consideration should be given to breastfeeding benefits and potential adverse effects on the infant.

Question 4

What are the effects of riluzole on fertility in rats?

Accepted Answer

In rats, oral administration of riluzole led to decreased fertility indices and increased embryolethality.

Question 5

Is riluzole safe and effective for pediatric use?

Accepted Answer

Safety and effectiveness for pediatric patients have not been established for riluzole.

Question 6

How does riluzole perform in elderly patients?

Accepted Answer

In clinical studies, no significant differences in safety or effectiveness were observed between elderly and younger patients. However, some older individuals might exhibit increased sensitivity.

Question 7

What considerations should be made for patients with hepatic impairment when using TIGLUTIK?

Accepted Answer

Patients with mild or moderate hepatic impairment might face increased risk of adverse reactions due to elevated riluzole exposure. TIGLUTIK is not recommended for certain patients with liver abnormalities.

Question 8

How does riluzole impact Japanese patients?

Accepted Answer

Japanese patients might have higher riluzole concentrations, potentially leading to a greater risk of adverse reactions.

Dosage & Administration

Get Your Patient on Tiglutik

Tiglutik Prescribing Information

Tiglutik Prior Authorization Resources

Most recent state uniform prior authorization forms

Benefits investigation

Tiglutik Preferred Pharmacy

Tiglutik Financial Assistance Options

Copay savings program

Overview

Patient benefit

Patient eligibility

How to sign up

Tiglutik PubMed™ News

Tiglutik Patient Education

Getting started on Tiglutik

Patient toolkit

Other resources

Tiglutik FAQs