Interleukin-23 Antagonists

Interleukin-23 Antagonist

Psoriasis

<section class="Section" data-sectioncode="34089-3"><a name="S11"></a><a name="section-9"></a><p></p><h1>11 DESCRIPTION</h1><p class="First">Guselkumab, an interleukin-23 antagonist, is a human immunoglobulin G1 lambda (IgG1λ) monoclonal antibody. Guselkumab is produced in a mammalian cell line using recombinant DNA technology and has an approximate molecular weight of approximately 147 kDa.</p><p>TREMFYA   <span class="Sup">®</span>(guselkumab) injection is a sterile, preservative free, clear, and colorless to light yellow solution. </p><div class="Section" data-sectioncode="42229-5"><a name="section-9.1"></a><p></p><p class="First"><span class="Underline">TREMFYA for Subcutaneous Injection</span></p><p>Available as a 100 mg/mL solution in a 1 mL or 2 mL glass prefilled syringe, in a 2 mL prefilled pen, or in a 1 mL One-Press patient-controlled injector for subcutaneous use.</p><p>Each TREMFYA 1 mL prefilled syringe or One-Press patient-controlled injector delivers 100 mg guselkumab, L-histidine (0.6 mg), L-histidine monohydrochloride monohydrate (1.5 mg), polysorbate 80 (0.5 mg), sucrose (79 mg) and water for injection at pH 5.8.</p><p>Each TREMFYA 2 mL prefilled syringe or prefilled pen (TREMFYA PEN) delivers 200 mg guselkumab, L-histidine (1.2 mg), L-histidine monohydrochloride monohydrate (3 mg), polysorbate 80 (1 mg), sucrose (158 mg) and water for injection at pH 5.8.</p></div><div class="Section" data-sectioncode="42229-5"><a name="section-9.2"></a><p></p><p class="First"><span class="Underline">TREMFYA for Intravenous Infusion</span></p><p>Available as 10 mg/mL solution in a 20 mL single-dose vial for intravenous use.</p><p>Each TREMFYA 20 mL vial delivers 200 mg guselkumab, EDTA disodium dihydrate (0.4 mg), L-histidine (11.3 mg), L-histidine monohydrochloride monohydrate (26.6 mg), L-methionine (8 mg), polysorbate 80 (10 mg), sucrose (1700 mg) and water for injection at pH 5.8.</p></div></section>

TREMFYA

guselkumab

Tremfya

1 ML guselkumab 100 MG/ML Prefilled Syringe

1 ML guselkumab 100 MG/ML Prefilled Syringe [Tremfya]

1 ML guselkumab 100 MG/ML Auto-Injector

1 ML guselkumab 100 MG/ML Auto-Injector [Tremfya]

20 ML guselkumab 10 MG/ML Injection

20 ML guselkumab 10 MG/ML Injection [Tremfya]

2 ML guselkumab 100 MG/ML Auto-Injector

2 ML guselkumab 100 MG/ML Auto-Injector [Tremfya]

2 ML guselkumab 100 MG/ML Prefilled Syringe

2 ML guselkumab 100 MG/ML Prefilled Syringe [Tremfya]

AxivaRx of Kansas

Adulhem

Cinqair

Entyvio

Fasenra

Ocrevus

Rituxan

Soliris

Stelara

Xolair

Tremfya | AxivaRx of Kansas

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