Dosage & Administration

IU, International Units; mcg, micrograms

ITP ( 2.1) (IV administration only)
Dose IUDose mcgRate of Administration
250 IU kg body weight50 mcg/kg body weightSingle injection over 3 to 5 minutes
Suppression of Rh Isoimmunization ( 2.1) (IV or IM administration only)
IndicationTimingDose (IV or IM)Dose (IV or IM)
Pregnancy and other obstetric conditionsIU (international units)mcg (micrograms)
Routine antepartum prophylaxis28-weeks
gestation
1,500 IU300 mcg
Postpartum prophylaxisWithin 72 hours of delivery600 IU120 mcg
Threatened abortionImmediately1,500 IU300 mcg
Amniocentesis and chorionic villus sampling before 34-weeks gestationImmediately after procedure1,500 IU300 mcg
Abortion, amniocentesis, or other manipulation after 34-weeks gestationWithin 72 hours600 IU120 mcg
Incompatible transfusions or massive fetal hemorrhageWithin 72 hours of exposureIV administration of 90 IU per 1 mL transfused RBC or per 2 mL transfused whole bloodIV administration of 18 mcg per 1 mL transfused RBC or per 2 mL transfused whole blood

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