Adult: iPTH same, increased or decreased by < 30% relative to baseline
Increase dose by 1 mcg daily or 2 mcg three times a week*
Adult: iPTH decreased by ≥ 30% and ≤ 60% relative to baseline
Maintain dose
Adult: iPTH decreased by > 60% or iPTH < 60 pg/mL relative to baseline
Decrease dose by 1 mcg daily or 2 mcg three times a week*
Pediatric: Ages 10 to 16 years
Increase each dose by 1 mcg three times a week every 4 weeks or decrease each dose by 1 mcg three times a week at any time based on iPTH, serum calcium and phosphorus levels.*
* Not more frequently than every other day when dosing three times a week.
Initial Dosage: CKD Stage 5
Adult
Dose (micrograms) = baseline iPTH (pg/mL) divided by 80. Administer dose orally three times a week.*
Pediatric: Ages 10 to 16 years
Dose (micrograms) = baseline iPTH (pg/mL) divided by 120. Administer dose orally three times a week.*
Dose Titration: CKD Stage 5
Adult
Dose in micrograms is based on most recent iPTH (pg/mL) divided by 80 with adjustments based on serum calcium and phosphorous levels. Dose three times a week.*
Pediatric: Ages 10 to 16 years
Increase each dose by 1 mcg three times a week every 4 weeks or decrease each dose by 2 mcg three times a week at any time based on iPTH, serum calcium and phosphorus levels.*
