Cluster Headache

<section class="Section" data-sectioncode="34089-3"><a name="s30"></a><a name="section-8"></a><p></p><h1>11 DESCRIPTION</h1><p class="First">Galcanezumab-gnlm is a humanized IgG4 monoclonal antibody specific for calcitonin-gene related peptide (CGRP) ligand. Galcanezumab-gnlm is produced in Chinese Hamster Ovary (CHO) cells by recombinant DNA technology. Galcanezumab-gnlm is composed of two identical immunoglobulin kappa light chains and two identical immunoglobulin gamma heavy chains and has an overall molecular weight of approximately 147 kDa.</p><p>EMGALITY (galcanezumab-gnlm) injection is a sterile, preservative-free, clear to opalescent and colorless to slightly yellow to slightly brown solution, for subcutaneous use. EMGALITY is supplied in a 1 mL single-dose prefilled pen to deliver 120 mg of galcanezumab-gnlm or a 1 mL single-dose prefilled syringe to deliver 100 mg or 120 mg of galcanezumab-gnlm. Each mL of solution contains 100 mg or 120 mg of galcanezumab-gnlm; L-histidine (0.5 mg); L-histidine hydrochloride monohydrate (1.5 mg); Polysorbate 80 (0.5 mg); Sodium Chloride (8.8 mg); Water for Injection, USP. The pH range is 5.3 - 6.3.</p></section>

EMGALITY

1 ML galcanezumab-gnlm 100 MG/ML Prefilled Syringe

1 ML galcanezumab-gnlm 100 MG/ML Prefilled Syringe [Emgality]

1 ML galcanezumab-gnlm 120 MG/ML Auto-Injector

1 ML galcanezumab-gnlm 120 MG/ML Auto-Injector [Emgality]

1 ML galcanezumab-gnlm 120 MG/ML Prefilled Syringe

1 ML galcanezumab-gnlm 120 MG/ML Prefilled Syringe [Emgality]

Emgality

galcanezumab

<section class="Section" data-sectioncode="34089-3"><a name="LINK_7ed0975d-d0c2-465e-aeef-d5e55e935595"></a><a name="section-8"></a><p></p><h1>11 DESCRIPTION</h1><p class="First">Eptinezumab-jjmr is a humanized immunoglobulin G1 (IgG1) monoclonal antibody specific for calcitonin gene-related peptide (CGRP) ligand. Eptinezumab-jjmr has an approximate molecular weight of 143 kD. Eptinezumab-jjmr is produced in <span class="Italics">Pichia pastoris</span> yeast cells by recombinant DNA technology. </p><p>VYEPTI (eptinezumab-jjmr) injection is a sterile, preservative-free, clear to slightly opalescent, colorless to brownish-yellow solution, for intravenous infusion. VYEPTI is supplied as a 100 mg/mL single-dose vial. Each mL contains 100 mg eptinezumab-jjmr formulated in L-histidine (1 mg), L-histidine hydrochloride monohydrate (2.8 mg), polysorbate 80 (0.15 mg), sorbitol (40.5 mg), and Water for Injection, USP, at a pH of 5.8.</p></section>

Vyepti

1 ML eptinezumab-jjmr 100 MG/ML Injection

1 ML eptinezumab-jjmr 100 MG/ML Injection [Vyepti]

eptinezumab

Emgality is a medication that can be self-administered once a month by injecting it subcutaneously under the skin. It is used for migraine prevention in adults and can also be used to treat cluster headaches during a cluster headache period. The most frequently reported side effect is injection site reactions. Additionally, there are no known drug interactions with Emgality.

Emgality is FDA approved for the following indications: Migraine and Cluster Headaches. 


Report Adverse Event 

Prescribing Information

Medication Guide 

Submit MSL Request 

Pharmacy List 

Online Sample Form 

Coverage Authorization Request 

Coverage Authorization Appeals: Migraine 

Letter of Medical Necessity: Migraine 

Coverage Authorization Appeals: Episodic Cluster Headache 

Letter of Medical Necessity: Episodic Cluster Headache 

Enroll in Savings Program

Lilly Cares Patient Assistance Program Eligibility Check 

Mechanism of Action (MOA)

Overall Safety Profile

Efficacy: Episodic Migraine 

Efficacy: Chronic Migraine 

Efficacy (During and Between Attacks - MSQ): Migraine

Efficacy (CONQUER including MIBS): Migraine 

Safety Profile: Migraine 

Dosing: Migraine 

Efficacy: Episodic Cluster Headache 

Dosing: Episodic Cluster Headache 

How To Rx in EMR 

Other HCP Resources 

About Emgality: Migraine 

Taking Emgality: Migraine 

Patient Stories: Migraine 

Migraine Patient Questionnaire

About Emgality: Episodic Cluster Headache 

Taking Emgality: Episodic Cluster Headache 

Instructions For Use (Video): Migraine 

Instructions For Use (Video) : Episodic Cluster Headache 

Instructions For Use (120mg Pen): Migraine 

Instructions For Use (120mg Syringe): Migraine 

Instructions For Use (100 mg Syringe): Episodic Cluster Headache

Vypeti is a prescription medication used for migraine prevention. It is administered as an intravenous infusion four times a year. The most common reported side effects were stuffy nose and scratchy throat. 

Vyepti is FDA approved for the following indications: Migraine prevention. 


Emgality®(galcanezumab)	Vyepti®(eptinezumab)

Prescription Only Emgality is a medication that can be self-administered once a month by injecting it subcutaneously under the skin. It is used for migraine prevention in adults and can also be...	Prescription Only Vypeti is a prescription medication used for migraine prevention. It is administered as an intravenous infusion four times a year. The most common reported side effects were...
Dosage & Administration
Administration
Subcutaneous. Learn more.	Intravenous infusion (must be diluted). Learn more.
Dosing
Migraine: 240 mg loading dose (120 mg x 2) followed by 120 mg monthly. . Learn more.	100 mg every 3 months or 300 mg (for some patients). Learn more.
Latin Shorthand
240 mg LD (120 mg x 2) then 120 mg/mo.. Learn more.	100 mg q3mo. Learn more.
Adverse Reactions
The most common adverse reactions (incidence ≥2% and at least 2% greater than placebo) in EMGALITY clinical studies were injection site reactions. . Learn more.	The most common adverse reactions (≥2% and 2% or greater than placebo) were nasopharyngitis and hypersensitivity.. Learn more.
Financial Assistance
Out-Of-Pocket Costs With Copay Card
$0. Learn more.	$0. Learn more.
Annual Cap
$4900. Learn more.	$200 per infusion for administration costs. Learn more.
Assistance Expiration
12 months. Learn more.	Calendar year. Learn more.
Generics
No lower-cost generic available	No lower-cost generic available

Emgality® Alternatives