Interleukin 4 Receptor alpha Antagonists

Interleukin-4 Receptor alpha Antagonist

Dermatitis, Atopic

<section class="Section" data-sectioncode="34089-3"><a name="S11"></a><a name="section-9"></a><p></p><h1>11 DESCRIPTION</h1><p class="First">Dupilumab, an interleukin-4 receptor alpha antagonist, is a human monoclonal antibody of the IgG4 subclass that binds to the IL-4Rα subunit and inhibits IL-4 and IL-13 signaling. Dupilumab has an approximate molecular weight of 147 kDa.</p><p>Dupilumab is produced by recombinant DNA technology in Chinese Hamster Ovary cell suspension culture.</p><p>DUPIXENT (dupilumab) Injection is supplied as a sterile, preservative-free, clear to slightly opalescent, colorless to pale yellow solution for subcutaneous injection. DUPIXENT is provided as either a single-dose pre-filled syringe with needle shield or a single-dose pre-filled pen in a siliconized Type-1 clear glass syringe. The needle cap is not made with natural rubber latex.</p><p>Each 300 mg pre-filled syringe or pre-filled pen delivers 300 mg dupilumab in 2 mL which also contains L-arginine hydrochloride (10.5 mg), L-histidine (6.2 mg), polysorbate 80 (4 mg), sodium acetate (2 mg), sucrose (100 mg), and water for injection, pH 5.9.</p><p>Each 200 mg pre-filled syringe or pre-filled pen delivers 200 mg dupilumab in 1.14 mL which also contains L-arginine hydrochloride (12 mg), L-histidine (3.5 mg), polysorbate 80 (2.3 mg), sodium acetate (1.2 mg), sucrose (57 mg), and water for injection, pH 5.9.</p></section>

Dupixent

dupilumab

2 ML dupilumab 150 MG/ML Prefilled Syringe

2 ML dupilumab 150 MG/ML Prefilled Syringe [Dupixent]

1.14 ML dupilumab 175 MG/ML Prefilled Syringe

1.14 ML dupilumab 175 MG/ML Prefilled Syringe [Dupixent]

2 ML dupilumab 150 MG/ML Auto-Injector

2 ML dupilumab 150 MG/ML Auto-Injector [Dupixent]

1.14 ML dupilumab 175 MG/ML Auto-Injector

1.14 ML dupilumab 175 MG/ML Auto-Injector [Dupixent]

0.67 ML dupilumab 150 MG/ML Prefilled Syringe

0.67 ML dupilumab 150 MG/ML Prefilled Syringe [Dupixent]

Clermont Oncology Center

Dupixent | Clermont Oncology Center

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