Interferon gamma

Bacterial Infections

Brain Neoplasms

Carcinoma, Renal Cell

Cryoglobulinemia

Hepatitis D

Hemangioma

Carcinoma, Hepatocellular

Ileal Neoplasms

Leukemia, Hairy Cell

Macular Degeneration

Melanoma

Multiple Myeloma

Mycosis Fungoides

Osteopetrosis

Sarcoma, Kaposi

Sezary Syndrome

Skin Neoplasms

Skin Ulcer

Thrombocythemia, Essential

Thrombocytopenia

Warts

Colorectal Neoplasms

Hypereosinophilic Syndrome

Hepatitis C, Chronic

<section class="Section" data-sectioncode="34089-3"><a name="S11"></a><a name="section-10"></a><p></p><h1>11 DESCRIPTION</h1><p class="First">ACTIMMUNE (Interferon gamma-1b), an interferon gamma, is a single-chain polypeptide containing 140 amino acids. Production of ACTIMMUNE is achieved by fermentation of a genetically engineered <span class="Italics">Escherichia coli</span> bacterium containing the DNA which encodes for the recombinant protein. Purification of the product is achieved by conventional column chromatography. ACTIMMUNE is a highly purified sterile solution consisting of non-covalent dimers of two identical 16,465 Dalton monomers; with a specific activity of 20 million International Units/mg (2 × 10<span class="Sup">6</span> International Units/0.5 mL) which is equivalent to 30 million units/mg.</p><p>ACTIMMUNE is a sterile, clear, colorless solution filled in a single-dose vial for subcutaneous injection. Each 0.5 mL of ACTIMMUNE contains: 100 mcg (2 million International Units) of interferon gamma-1b formulated in disodium succinate hexahydrate (0.37 mg), mannitol (20 mg), polysorbate 20 (0.05 mg), succinic acid (0.14 mg) and Sterile Water for Injection. Note that the above activity is expressed in International Units (1 million International Units/50 mcg). This is equivalent to what was previously expressed as units (1.5 million units/50 mcg).</p></section>

ACTIMMUNE

0.5 ML interferon gamma-1b 0.2 MG/ML Injection

Actimmune

interferon gamma-1b

0.5 ML interferon gamma-1b 0.2 MG/ML Injection [Actimmune]

Psoriasis (PsO)

Psoriatic Arthritis (PsA)

Ankylosing Spondylitis (AS)

Nonradiographic Axial Spondyloarthritis

Taltz

Juvenile Idiopathic Arthritis

Hidradenitis Suppurativa (HS)

Cosentyx

Siliq

Tremfya

Crohn's Disease (CD)

Ulcerative Colitis (UC)

Stelara

Skyrizi

Ilumya

Migraine

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Migraine Prevention

Emgality

Qulipta

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Vyepti

Aimovig

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Breast Cancer: HR+ (HER2-)

Verzenio

Ibrance

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Cibinqo

Eucrisa

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Asthma OCS Dependent

Nasal Polyposis

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Prurigo Nodularis

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About Actimmune: Chronic Granulomatous Disease (CGD)

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Patient Stories: Chronic Granulomatous Disease (CGD)

Taking Actimmune: Chronic Granulomatous Disease (CGD)

Instructions for Use: Chronic Granulomatous Disease (CGD)

Patient Resources: Chronic Granulomatous Disease (CGD)

Doctor Discussion Guide: Chronic Granulomatous Disease (CGD)

Chronic Granulomatous Disease (CGD) Facts 

Managing Side Effects: Chronic Granulomatous Disease (CGD)

Nurse Advocate Center: Chronic Granulomatous Disease (CGD)

About Actimmune: Severe Malignant Osteopetrosis (SMO)

Patient Resources: Severe Malignant Osteopetrosis  (SMO)

Managing Severe Malignant Osteopetrosis (SMO)

Instructions for Use: Severe Malignant Osteopetrosis (SMO)

Comprehensive Support Program : CGD