eGFR | Recommended Dose |
eGFR 45 or greater | To improve glycemic control, the recommended starting dose is 5 mg orally once daily. Dose can be increased to 10 mg orally once daily for additional glycemic control. For all other indications, the recommended starting dose is 10 mg orally once daily. |
eGFR 25 to less than 45 | 10 mg orally once daily |
eGFR less than 25 | Initiation is not recommended, however patients may continue 10 mg orally once daily to reduce the risk of eGFR decline, ESKD, CV death and hHF. |
On dialysis | Contraindicated |