GLP-1 Receptor Agonist

Glucagon-like Peptide-1 (GLP-1) Agonists

Type 2 Diabetes Mellitus

<section class="Section" data-sectioncode="34089-3"><a name="s55"></a><a name="section-10"></a><p></p><h1>11 DESCRIPTION</h1><p class="First">Dulaglutide is a human glucagon-like peptide-1 (GLP-1) receptor agonist. The molecule is a fusion protein that consists of 2 identical, disulfide-linked chains, each containing an N-terminal GLP-1 analog sequence covalently linked to the Fc portion of a modified human immunoglobulin G4 (IgG4) heavy chain by a small peptide linker and is produced using mammalian cell (Chinese hamster ovary) culture. The GLP-1 analog portion of dulaglutide is 90% homologous to native human GLP-1 (7-37). Structural modifications were introduced in the GLP-1 part of the molecule responsible for interaction with the enzyme dipeptidyl-peptidase-IV (DPP-4). Additional modifications were made in an area with a potential T-cell epitope and in the areas of the IgG4 Fc part of the molecule responsible for binding the high-affinity Fc receptors and half-antibody formation. The overall molecular weight of dulaglutide is approximately 63 kilodaltons.</p><p>TRULICITY (dulaglutide) injection is a clear, colorless, sterile, preservative-free solution for subcutaneous use. Each single-dose pen contains a 0.5 mL solution of 0.75 mg, 1.5 mg, 3 mg, or 4.5 mg of dulaglutide and the following excipients: citric acid anhydrous (0.07 mg), mannitol (23.2 mg), polysorbate 80 (0.10 mg for 0.75 mg and 1.5 mg; 0.125 mg for 3 mg and 4.5 mg), and trisodium citrate dihydrate (1.37 mg), in water for injection.</p></section>

Trulicity

0.5 ML dulaglutide 1.5 MG/ML Auto-Injector

0.5 ML dulaglutide 1.5 MG/ML Auto-Injector [Trulicity]

0.5 ML dulaglutide 3 MG/ML Auto-Injector

0.5 ML dulaglutide 3 MG/ML Auto-Injector [Trulicity]

0.5 ML dulaglutide 6 MG/ML Auto-Injector

0.5 ML dulaglutide 6 MG/ML Auto-Injector [Trulicity]

0.5 ML dulaglutide 9 MG/ML Auto-Injector

0.5 ML dulaglutide 9 MG/ML Auto-Injector [Trulicity]

dulaglutide

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