Kinase Inhibitor

Kinase Inhibitors

Non-Small-Cell Lung Carcinoma

<section class="Section" data-sectioncode="34089-3"><a name="S11"></a><a name="section-9"></a><p></p><h1>11 DESCRIPTION</h1><p class="First">ALECENSA (alectinib) is a kinase inhibitor for oral administration. The molecular formula for alectinib is C<span class="Sub">30</span>H<span class="Sub">34</span>N<span class="Sub">4</span>O<span class="Sub">2</span> ∙ HCl. The molecular weight is 482.62 g/mol (free base form) and 519.08 g/mol (hydrochloride salt). Alectinib is described chemically as 9-ethyl-6, 6-dimethyl-8-[4-(morpholin-4-yl)piperidin-1-yl]-11-oxo-6, 11-dihydro-5<span class="Italics">H</span>-benzo[<span class="Italics">b</span>]carbazole-3-carbonitrile hydrochloride. The chemical structure of alectinib is shown below: </p><div class="Figure"><img alt="Chemical Structure" src="alecensa-01.jpg"/></div><p>Alectinib HCl is a white to yellow white powder or powder with lumps with a pKa of 7.05 (base). </p><p>ALECENSA is supplied as hard capsules containing 150 mg of alectinib (equivalent to 161.33 mg alectinib HCl) and the following inactive ingredients: lactose monohydrate, hydroxypropylcellulose, sodium lauryl sulfate, magnesium stearate, and carboxymethylcellulose calcium. The capsule shell contains hypromellose, carrageenan, potassium chloride, titanium dioxide, corn starch, and carnauba wax. The printing ink contains red iron oxide (E172), yellow iron oxide (E172), FD&amp;C Blue No. 2 aluminum lake (E132), carnauba wax, white shellac, and glyceryl monooleate.</p></section>

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