* Day 1: 10 mg in morning * Day 2: 10 mg in morning and 10 mg in evening * Day 3: 10 mg in morning and 20 mg in evening * Day 4: 20 mg in morning and 20 mg in evening * Day 5: 20 mg in morning and 30 mg in evening * Day 6 and thereafter: 30 mg twice daily * Dosage in Severe Renal Impairment: * Recommended dose is 30 mg once daily. * For initial dosage titration, titrate using only morning schedule listed in Table 1 and skip afternoon doses.
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Otezla prescribing information
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