Calcium Chloride
Calcium Chloride Prescribing Information
Calcium Chloride Injection is indicated for the treatment of adult and pediatric patients with acute symptomatic hypocalcemia.
The safety and effectiveness of Calcium Chloride Injection for long-term use has not been established.
Calcium Chloride Injection, USP (single-dose) supplied as:
- 10% 1 gram/10 mL (100 mg/mL) in a glass vial.
The 100 mg/mL concentration represents 27 mg or 1.4 mEq of elemental calcium per mL of solution.
Calcium Chloride Injection is contraindicated in:
- Patients with ventricular fibrillation
- Patients with asystole and electromechanical dissociation
Newborns (up to 28 days of age) if they require (or are expected to require) ceftriaxone intravenous treatment because of the risk of precipitation of ceftriaxone-calcium, regardless of whether these products would be received at different times or through separate intravenous lines
The following serious adverse reactions are also described elsewhere in the labeling:
• End-Organ Damage due to Intravascular Ceftriaxone-Calcium Precipitates
• Hypotension, Bradycardia, Arrhythmias, and Syncope with Rapid Administration
• Arrhythmias with Concomitant Digoxin Use
• Tissue Necrosis and Calcinosis
• Aluminum toxicity
The following adverse reactions have been identified in literature and postmarketing reports of calcium chloride. Because some of these reactions were reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure:
• Nervous system disorders: Paraesthesia (upon rapid injection), calcium taste
• General disorders and administration site conditions: Sense of oppression, sense of “heat wave”, local burning sensation, injection site extravasation, injection site reactions
• Cardiovascular disorders: Peripheral vasodilatation, decreased blood pressure
10% Calcium Chloride Injection, USP is a sterile, nonpyrogenic, hypertonic solution for single administration only. Each mL contains 100 mg (1.4 mEq/mL) of calcium chloride, dihydrate (1.4 mEq each of Ca++ and Cl
Calcium Chloride, USP dihydrate is chemically designated CaCl2 • 2H2O (dihydrate) and is described as white, odorless fragments or granules freely soluble in water.
Calcium Chloride Injection, USP contains no more than 1,000 mcg/L of aluminum
Calcium Chloride Injection, USP (clear solution) is supplied in single-dose vials as follows:
Unit of Sale and Product Description | Strength | NDC |
Each carton contains 10 single-dose vials. | 10% (1,000 mg/10 mL) | 72572- 052 -10 |
The 100 mg/mL concentration represents 27 mg or 1.4 mEq of elemental calcium per mL of solution.
Store at 20°C to 25°C (68°F to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F). [See USP Controlled Room Temperature.]