Norepinephrine Uptake Inhibitors

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Alcoholism

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<section class="Section" data-sectioncode="34089-3"><a name="S11"></a><a name="section-11"></a><p></p><h1>11 DESCRIPTION</h1><p class="First">CONTRAVE extended-release tablets contain naltrexone hydrochloride (HCl) and bupropion HCl.</p><p>Naltrexone HCl, USP, an opioid antagonist, is a synthetic congener of oxymorphone with no opioid agonist properties. Naltrexone differs in structure from oxymorphone in that the methyl group on the nitrogen atom is replaced by a cyclopropylmethyl group. Naltrexone HCl is also related to the potent opioid antagonist, naloxone, or n-allylnoroxymorphone.</p><p>Naltrexone HCl has the chemical name of morphinan-6-one, 17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-, hydrochloride, (5α)-. The empirical formula is C<span class="Sub">20</span>H<span class="Sub">23</span>NO<span class="Sub">4</span>∙HCl and the molecular weight is 377.86. The structural formula is:</p><div class="Figure"><img alt="Chemical Structure" src="contrave-02.jpg"/></div><p>Naltrexone HCl is a white to yellowish, crystalline compound. It is soluble in water to the extent of about 100 mg/mL.</p><p>Bupropion HCl is an antidepressant of the aminoketone class. Bupropion HCl closely resembles the structure of diethylpropion. It is designated as (±)-1-(3 chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propranone hydrochloride. It is related to phenylethylamines. The empirical formula is C<span class="Sub">13</span>H<span class="Sub">18</span>ClNO∙HCl and the molecular weight is 276.2. The structural formula is:</p><div class="Figure"><img alt="Chemical Structure" src="contrave-03.jpg"/></div><p>Bupropion HCl powder is white, crystalline, and highly soluble in water.</p><p>CONTRAVE is available for oral administration as a round, bi-convex, film-coated, extended-release tablet. Each tablet has a trilayer core composed of two drug layers, containing the drug and excipients, separated by a more rapidly dissolving inert layer. Each tablet contains 8 mg of naltrexone HCl and 90 mg of bupropion HCl. Tablets are blue and are debossed with NB-890 on one side. Each tablet contains the following inactive ingredients: microcrystalline cellulose, hydroxypropyl cellulose, lactose anhydrous, L-cysteine hydrochloride, crospovidone, magnesium stearate, hypromellose, edetate disodium, lactose monohydrate, colloidal silicon dioxide, Opadry II Blue and FD&amp;C Blue #2 aluminum lake.</p></section>

Contrave

naltrexone hydrochloride

bupropion / naltrexone

12 HR bupropion hydrochloride 90 MG / naltrexone hydrochloride 8 MG Extended Release Oral Tablet

12 HR bupropion hydrochloride 90 MG / naltrexone hydrochloride 8 MG Extended Release Oral Tablet [Contrave]

bupropion hydrochloride

bupropion

naltrexone

Psoriasis (PsO)

Psoriatic Arthritis (PsA)

Ankylosing Spondylitis (AS)

Nonradiographic Axial Spondyloarthritis

Taltz

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Cosentyx

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Ilumya

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Qulipta

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Ubrelvy

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Verzenio

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Entyvio

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Prescribing Information

Medication Guide 

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About Contrave 

Personalised Weight Loss Assessment Guide

FAQs: Weight Management 

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Instructions For Use: Weight Management 