Desflurane
Desflurane Prescribing Information
Contraindications (4) 11/2022
Warnings and Precautions; Malignant Hyperthermia (5.1) 11/2022
Desflurane, USP, Liquid for Inhalation, a general anesthetic, is an inhalation agent indicated:
- for induction and/or maintenance of anesthesia in adults ()
1.1 Induction of AnesthesiaDesflurane, USP, Liquid for Inhalation is indicated as an inhalation agent for induction of anesthesia for inpatient and outpatient surgery in adults.
Desflurane, USP, Liquid for Inhalation is contraindicated as an inhalation agent for the induction of anesthesia in pediatric patients because of a high incidence of moderate to severe upper airway adverse events.
- for maintenance of anesthesia in pediatric patients following induction with agents other than Desflurane, USP, Liquid for Inhalation and intubation.
Yellow discoloration of Desflurane, USP, Liquid for Inhalation sometimes accompanied by particulates, has been observed through the vaporizer sight glass or after draining the vaporizer. The presence of discoloration or particulates in these situations does not alter the quality or efficacy of Desflurane, USP, Liquid for Inhalation. If observed, refer to the respective vaporizer Instructions For Use (IFU) for recommended actions or contact Sandoz Product Surveillance.
Desflurane, USP, Liquid for Inhalation is a colorless, non-flammable, volatile liquid (below 22.8°C) for inhalation, 100% desflurane.
- Geriatric Use:The minimum alveolar concentration (MAC) of desflurane decreases with increasing patient age. ()
8.5 Geriatric UseThe minimum alveolar concentration (MAC) of desflurane decreases with increasing patient age. The dose should be adjusted accordingly. The average MAC for desflurane in a 70 year old patient is two-thirds the MAC for a 20 year old patient
[See Dosage and Administration (2) Table 1and Clinical Studies (14.3)].
The use of Desflurane, USP, Liquid for Inhalation is contraindicated in the following conditions:
- Known or suspected genetic susceptibility to malignant hyperthermia[See Warnings and Precautions (5.1), Clinical Pharmacology (12.5)].
- Patients in whom general anesthesia is contraindicated.
- Induction of anesthesia in pediatric patients.
- Patients with known sensitivity to Desflurane, USP, Liquid for Inhalation or to other halogenated agents [See
5.6 Hepatobiliary DisordersWith the use of halogenated anesthetics, disruption of hepatic function, icterus and fatal liver necrosis have been reported; such reactions appear to indicate hypersensitivity. As with other halogenated anesthetic agents, desflurane may cause sensitivity hepatitis in patients who have been sensitized by previous exposure to halogenated anesthetics
[See Contraindications (4)]. Cirrhosis, viral hepatitis or other pre-existing hepatic disease may be a reason to select an anesthetic other than a halogenated anesthetic. As with all halogenated anesthetics, repeated anesthesia within a short period of time should be approached with caution.]. - Patients with a history of moderate to severe hepatic dysfunction following anesthesia with Desflurane, USP, Liquid for Inhalation or other halogenated agents and not otherwise explained [See
5.6 Hepatobiliary DisordersWith the use of halogenated anesthetics, disruption of hepatic function, icterus and fatal liver necrosis have been reported; such reactions appear to indicate hypersensitivity. As with other halogenated anesthetic agents, desflurane may cause sensitivity hepatitis in patients who have been sensitized by previous exposure to halogenated anesthetics
[See Contraindications (4)]. Cirrhosis, viral hepatitis or other pre-existing hepatic disease may be a reason to select an anesthetic other than a halogenated anesthetic. As with all halogenated anesthetics, repeated anesthesia within a short period of time should be approached with caution.].