Enoxaparin Sodium

• Use of indwelling epidural catheters
• Concomitant use of other drugs that affect hemostasis, such as non-steroidal anti-inflammatory drugs (NSAIDs), platelet inhibitors, and other anticoagulants
• A history of traumatic or repeated epidural or spinal punctures
• A history of spinal deformity or spinal surgery
• Optimal timing between the administration of enoxaparin sodium and neuraxial procedures is not known

Enoxaparin sodium is a low molecular weight heparin (LMWH) indicated for:

• Prophylaxis of deep vein thrombosis (DVT) in abdominal surgery, hip replacement surgery, knee replacement surgery, or medical patients with severely restricted mobility during acute illness (
  
  
  1.1)
  
  
• Inpatient treatment of acute DVT with or without pulmonary embolism (
  
  
  1.2)
  
  
• Outpatient treatment of acute DVT without pulmonary embolism (
  
  
  1.2)
  
  
• Prophylaxis of ischemic complications of unstable angina and non–Q-wave myocardial infarction (MI) (
  
  
  1.3)
  
  
• Treatment of acute ST-segment elevation myocardial infarction (STEMI) managed medically or with subsequent percutaneous coronary intervention (PCI) (
  
  
  1.4)
  
  

See full prescribing information for dosing and administration information. (

2)

Enoxaparin sodium injection is a clear, colorless to pale-yellow solution available in two concentrations.

• Severe Renal Impairment: Adjust dose for patients with creatinine clearance <30 mL/min. (
  
  
  2.3,
  
  
  8.7)
  
  
• Geriatric Patients: Monitor for increased risk of bleeding. (
  
  
  8.5)
  
  
• Low-Weight Patients: Observe for signs of bleeding. (
  
  
  8.8)