Gonadotropin Releasing Hormone Receptor Antagonists

Gonadotropin Releasing Hormone Receptor Antagonist

Prostatic Neoplasms

<section class="Section" data-sectioncode="34089-3"><a name="S11"></a><a name="section-10"></a><p></p><h1>11 DESCRIPTION</h1><p class="First">FIRMAGON is a sterile lyophilized powder for injection containing degarelix (as the acetate) and mannitol. Degarelix is a synthetic linear decapeptide amide containing seven unnatural amino acids, five of which are D-amino acids. The acetate salt of degarelix is a white to off-white amorphous powder of low density as obtained after lyophilization.</p><p>The chemical name of degarelix is D-Alaninamide, <span class="Italics">N</span>-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-4-[[[(4S)-hexahydro-2,6-dioxo-4-pyrimidinyl]carbonyl]amino]-L phenylalanyl-4-[(aminocarbonyl)amino]-D-phenylalanyl-L-leucyl-<span class="Italics">N</span>6–(1-methylethyl)-L-lysyl-L-prolyl. It has an empirical formula of C<span class="Sub">82</span>H<span class="Sub">103</span>N<span class="Sub">18</span>O<span class="Sub">16</span>Cl and a molecular weight of 1632.3 Da.</p><p>Degarelix acetate has the following structural formula:</p><div class="Figure"><img alt="Chemical Structure" src="firmagon-23.jpg"/></div><p>FIRMAGON is available in two packaging configurations:</p><ul class="Disc"><li>Starting Dose: Two vial carton with each vial delivering 120 mg of degarelix (equivalent to the median value of 126 mg degarelix acetate).  Each 120 mg dose contains 150 mg mannitol.</li><li>Maintenance Dose: One-vial carton delivering 80 mg of degarelix (equivalent to the median value of 84 mg degarelix acetate). Each 80 mg dose contains 200 mg mannitol.</li></ul></section>

FIRMAGON

degarelix

degarelix 80 MG Injection

degarelix 120 MG Injection

Firmagon

degarelix 80 MG Injection [Firmagon]

degarelix 120 MG Injection [Firmagon]

Psoriasis (PsO)

Psoriatic Arthritis (PsA)

Ankylosing Spondylitis (AS)

Nonradiographic Axial Spondyloarthritis

Taltz

Juvenile Idiopathic Arthritis

Hidradenitis Suppurativa (HS)

Cosentyx

Siliq

Tremfya

Crohn's Disease (CD)

Ulcerative Colitis (UC)

Stelara

Skyrizi

Ilumya

Migraine

Cluster Headache

Migraine Prevention

Emgality

Qulipta

Acute Migraine

Ubrelvy

Nurtec ODT

Vyepti

Aimovig

Ajovy

Breast Cancer: HR+ (HER2-)

Verzenio

Ibrance

Kisqali

Atopic Dermatitis (Eczema)

Cibinqo

Eucrisa

Asthma (injectable)

Asthma OCS Dependent

Nasal Polyposis

Eosinophilic Esophagitis (EoE)

Prurigo Nodularis

Dupixent

Opzelura

Adbry

NSCLC ALK+ OR ROS1+ Disease

Lorbrena

Alecensa

Alunbrig

NSCLC cMET Mutation

Xalkori

Rheumatoid Arthritis (RA)

Xeljanz

Uveitis

Graft Versus Host Disease (GVHD)

Orencia

COVID-19 Treatment

Alopecia Areata

Olumiant

Multiple Sclerosis (MS)

Secondary Progressive Multiple Sclerosis

Zeposia

Rinvoq

Entyvio

Report Adverse Event 

Prescribing Information

Medication Guide - Page 19

Submit MSL Request 

Pharmacy List 

How To Order Firmagon

Billing & Coding Guide 

Reimbursement Information

Firmagon Reimbursement & Support Portal - HCP Office 

Coverage Authorization Request 

Coverage Authorization Appeals 

Enroll in Patient Savings Program 

About Firmagon 

Before Treatment: What To Ask Your Treatment Team

Receiving Firmagon 

Side Effects 

Caregiver Support

FAQs: Advanced Prostate Cancer 

Instructions For Use: Advacned Prostate Cancer 

Testosterone & PSA Tracker 

Patient Brochure 

Healthy Living Guide 