Organic Anion Transporting Polypeptide 2B1 Inhibitors

Sodium-Hydrogen Exchanger 3 Inhibitor

Sodium-Hydrogen Exchanger 3 Inhibitors

Irritable Bowel Syndrome

<section class="Section" data-sectioncode="34089-3"><a name="S11"></a><a name="section-10"></a><p></p><h1>11 DESCRIPTION</h1><p class="First">IBSRELA (tenapanor) tablets contain tenapanor hydrochloride as an active ingredient. Tenapanor hydrochloride is a sodium/hydrogen exchanger 3 (NHE3) inhibitor for oral use. The chemical name for tenapanor hydrochloride is 12,15-Dioxa-2,7,9-triazaheptadecanamide, 17-[[[3-[(4S)-6,8-dichloro-1,2,3,4-tetrahydro-2-methyl-4-isoquinolinyl]phenyl]sulphonyl]amino]-N-[2-[2-[2-[[[3-[(4S)-6,8-dichloro-1,2,3,4-tetrahydro-2-methyl-4-isoquinolinyl]phenyl]sulphonyl]amino]ethoxy]ethoxy]ethyl]-8-oxo-, hydrochloride (1:2). Tenapanor hydrochloride has the molecular formula of C<span class="Sub">50</span>H<span class="Sub">68</span>Cl<span class="Sub">6</span>N<span class="Sub">8</span>O<span class="Sub">10</span>S<span class="Sub">2</span>, the molecular weight of 1218 Daltons, and the chemical structure below: </p><div class="Figure"><img alt="Chemical Structure" src="ibsrela-02.jpg"/></div><p>Tenapanor hydrochloride is a white to off-white to light brown hygroscopic amorphous solid. It is practically insoluble in water.</p><p>IBSRELA tablets contain 50 mg of tenapanor (equivalent to 53.2 mg of tenapanor hydrochloride). Inactive ingredients in the tablet are colloidal silicon dioxide, hypromellose, low-substituted hydroxypropyl cellulose, microcrystalline cellulose, propyl gallate, stearic acid, tartaric acid powder, titanium dioxide and triacetin.</p></section>

IBSRELA

tenapanor

tenapanor 50 MG Oral Tablet

Ibsrela

tenapanor 50 MG Oral Tablet [Ibsrela]

Psoriasis (PsO)

Psoriatic Arthritis (PsA)

Ankylosing Spondylitis (AS)

Nonradiographic Axial Spondyloarthritis

Taltz

Juvenile Idiopathic Arthritis

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Cosentyx

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Stelara

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Other HCP Resources 

Other HCP Resources: Video

About Ibsrela Patient Handout - Spanish

About Ibsrela Patient Handout 

About Ibsrela 

Taking Ibsrela 

Side Effects 

Instructions For Use: Irritable Bowel Syndrome with Constipation