Melanocortin 4 Receptor Agonist

Melanocortin 4 Receptor Agonists

<section class="Section" data-sectioncode="34089-3"><a name="s_1100"></a><a name="section-9"></a><h1>11 DESCRIPTION</h1>IMCIVREE contains setmelanotide acetate, a melanocortin 4 (MC4) receptor agonist. Setmelanotide is an 8 amino acid cyclic peptide analog of endogenous melanocortin peptide α-MSH (alpha-melanocyte stimulating hormone).The chemical name for setmelanotide acetate is acetyl-L-arginyl-L-cysteinyl-D-alanyl-L-histidinyl-D-phenylalanyl-L-arginyl-L-tryptophanyl-L-cysteinamide cyclic (2→8)-disulfide acetate. Its molecular formula is C49H68N18O9S2 (anhydrous, free-base), and molecular mass is 1117.3 Daltons (anhydrous, free-base).The chemical structure of setmelanotide acetate is:<img alt="CHEMICAL-STRUCTURES" src="imcivree-01.jpg"/>IMCIVREE (setmelanotide) injection is a sterile clear to slightly opalescent, colorless to slightly yellow solution for subcutaneous use. Each 1 mL of IMCIVREE contains 10 mg of setmelanotide provided as setmelanotide acetate, which is a salt with 2 to 4 molar equivalents of acetate, and the following inactive ingredients: 10 mg benzyl alcohol, 8 mg carboxymethylcellulose sodium (average MWt 90,500), 1 mg edetate disodium dihydrate, 100 mg N-(carbonyl-methoxypolyethylene glycol 2000)-1,2-distearoyl- glycero-3- phosphoethanolamine sodium salt, 11 mg mannitol, 5 mg phenol, and Water for Injection. The pH of IMCIVREE is 5 to 6.</section>

Imcivree

setmelanotide

setmelanotide 10 MG/ML Injectable Solution

setmelanotide 10 MG/ML Injectable Solution [Imcivree]

Psoriasis (PsO)

Psoriatic Arthritis (PsA)

Ankylosing Spondylitis (AS)

Nonradiographic Axial Spondyloarthritis

Taltz

Juvenile Idiopathic Arthritis

Hidradenitis Suppurativa (HS)

Cosentyx

Siliq

Tremfya

Crohn's Disease (CD)

Ulcerative Colitis (UC)

Stelara

Skyrizi

Ilumya

Migraine

Cluster Headache

Migraine Prevention

Emgality

Qulipta

Acute Migraine

Ubrelvy

Nurtec ODT

Vyepti

Aimovig

Ajovy

Breast Cancer: HR+ (HER2-)

Verzenio

Ibrance

Kisqali

Atopic Dermatitis (Eczema)

Cibinqo

Eucrisa

Asthma (injectable)

Asthma OCS Dependent

Nasal Polyposis

Eosinophilic Esophagitis (EoE)

Prurigo Nodularis

Dupixent

Opzelura

Adbry

NSCLC ALK+ OR ROS1+ Disease

Lorbrena

Alecensa

Alunbrig

NSCLC cMET Mutation

Xalkori

Rheumatoid Arthritis (RA)

Xeljanz

Uveitis

Graft Versus Host Disease (GVHD)

Orencia

COVID-19 Treatment

Alopecia Areata

Olumiant

Multiple Sclerosis (MS)

Secondary Progressive Multiple Sclerosis

Zeposia

Rinvoq

Entyvio

Report Adverse Event 

Prescribing Information 

Medication Guide 

Submit MSL Request 

Pharmacy List 

Coverage Authorization Request 

Coverage Authorization Appeals 

Imcivree Start Form 

Enroll in Patient Savings Program 

Other HCP Resources: POMC, PCSK1, or LEPR Deficiency

Other HCP Resources: Bardet Biedl Syndrome (BBS)

Rhythm InTune Support Program 

Imcivree Start Guide 

Rhythm InTune Support Program Brochure 

Treatment Journal 

Treatment Journal - Spanish

Side Effects: POMC, PCSK1, or LEPR Deficiency

Taking Imcivree: POMC, PCSK1, or LEPR Deficiency

Understanding Your Dose: POMC, PCSK1, or LEPR Deficiency

FAQs: POMC, PCSK1, or LEPR Deficiency

Patient Resources: POMC, PCSK1, or LEPR Deficiency

Instructions For Use: POMC, PCSK1, or LEPR Deficiency

Patient Brochure: POMC, PCSK1, or LEPR Deficiency

About Imcivree: Bardet Biedl Syndrome (BBS)

Side Effects: Bardet Biedl Syndrome (BBS)

Taking Imcivree: Bardet Biedl Syndrome (BBS)

Understanding Your Dose: Bardet Biedl Syndrome (BBS)

FAQs: Bardet Biedl Syndrome (BBS)

Patient Resources: Bardet Biedl Syndrome (BBS)

Instructions For Use: Bardet Biedl Syndrome (BBS)

Patient Brochure: Bardet Biedl Syndrome (BBS)

Patient Brochure (Spanish): Bardet Biedl Syndrome (BBS)

Getting Started With Imcivree Brochure: Bardet Biedl Syndrome (BBS)

Getting Started With Imcivree Brochure (Spanish): Bardet Biedl Syndrome (BBS)