Endothelin Receptor Antagonists

Endothelin Receptor Antagonist

Hypertension, Pulmonary

<section class="Section" data-sectioncode="34089-3"><a name="S11"></a><a name="section-10"></a><h1>11 DESCRIPTION</h1>Letairis is the brand name for ambrisentan, an endothelin receptor antagonist that is selective for the endothelin type-A (ET A) receptor. The chemical name of ambrisentan is (+)-(2 S)-2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropanoic acid. It has a molecular formula of C 22H 22N 2O 4 and a molecular weight of 378.42. It contains a single chiral center determined to be the ( S) configuration and has the following structural formula: Figure 1 Ambrisentan Structural Formula<img alt="Chemical Structure" src="letairis-01.jpg"/>Ambrisentan is a white to off-white, crystalline solid. It is a carboxylic acid with a pKa of 4.0. Ambrisentan is practically insoluble in water and in aqueous solutions at low pH. Solubility increases in aqueous solutions at higher pH. In the solid state ambrisentan is very stable, is not hygroscopic, and is not light sensitive.Letairis is available as 5 mg and 10 mg film-coated tablets for once daily oral administration. The tablets include the following inactive ingredients: croscarmellose sodium, lactose monohydrate, magnesium stearate and microcrystalline cellulose. The tablets are film-coated with a coating material containing FD&amp;C Red #40 aluminum lake, lecithin, polyethylene glycol, polyvinyl alcohol, talc, and titanium dioxide. Each square, pale pink Letairis tablet contains 5 mg of ambrisentan. Each oval, deep pink Letairis tablet contains 10 mg of ambrisentan. Letairis tablets are unscored.</section>

Letairis

ambrisentan

ambrisentan 10 MG Oral Tablet

ambrisentan 10 MG Oral Tablet [Letairis]

ambrisentan 5 MG Oral Tablet

ambrisentan 5 MG Oral Tablet [Letairis]

Psoriasis (PsO)

Psoriatic Arthritis (PsA)

Ankylosing Spondylitis (AS)

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Taltz

Juvenile Idiopathic Arthritis

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Cosentyx

Siliq

Tremfya

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Verzenio

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About Letairis

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Instructions For Use: Pulmonary Arterial Hypertension