Nucleic Acid Synthesis Inhibitors

Nucleoside Analog Antiviral

Nucleoside Metabolic Inhibitor

Thymidine Phosphorylase Inhibitors

Thymidine Phosphorylase Inhibitor

Keratoconjunctivitis, Infectious

Colorectal Neoplasms

Keratitis, Herpetic

<section class="Section" data-sectioncode="34089-3"><a name="S11"></a><a name="section-8"></a><h1>11 DESCRIPTION</h1>LONSURF contains trifluridine and tipiracil hydrochloride at a molar ratio of 1:0.5.TrifluridineTrifluridine, a nucleoside metabolic inhibitor, is described chemically as 2’-deoxy-5-(trifluoromethyl) uridine and has the following structural formula:<img alt="Trifluridine " src="lonsurf-figure-1.jpg"/>Trifluridine has a molecular formula C10H11F3N2O5 and a molecular weight of 296.20. Trifluridine is a white crystalline powder, soluble in water, ethanol, 0.01 mol/L hydrochloric acid, 0.01 mol/L sodium hydroxide solution; freely soluble in methanol, acetone; sparingly soluble in 2-propanol, acetonitrile; slightly soluble in diethyl ether; and very slightly soluble in isopropyl ether.Tipiracil hydrochlorideTipiracil hydrochloride, a thymidine phosphorylase inhibitor, is described chemically as 5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]pyrimidine-2,4-(1H,3H)-dione monohydrochloride or 2,4(1H,3H)-Pyrimidinedione, 5-chloro-6-[(2-imino-1-pyrrolidinyl)methyl]-, hydrochloride (1:1) and has the following structural formula:<img alt="Tipiracil hydrochloride" src="lonsurf-figure-2.jpg"/>Tipiracil hydrochloride has a molecular formula C9H11ClN4O2•HCl and a molecular weight of 279.12. Tipiracil hydrochloride is a white crystalline powder, soluble in water, 0.01 mol/L hydrochloric acid, and 0.01 mol/L sodium hydroxide; slightly soluble in methanol; very slightly soluble in ethanol; and practically insoluble in acetonitrile, 2-propanol, acetone, diisopropyl ether, and diethyl ether.LONSURF (trifluridine and tipiracil) tablets for oral use contain 15 mg of trifluridine and 6.14 mg of tipiracil equivalent to 7.065 mg of tipiracil hydrochloride or 20 mg of trifluridine and 8.19 mg of tipiracil equivalent to 9.420 mg of tipiracil hydrochloride.LONSURF tablets contain the following inactive ingredients: lactose monohydrate, pregelatinized starch, stearic acid, hypromellose, polyethylene glycol, titanium dioxide, ferric oxide, and magnesium stearate. The tablets are imprinted with ink containing shellac, ferric oxide red, ferric oxide yellow, titanium dioxide, FD&amp;C Blue No. 2 Aluminum Lake, carnauba wax, and talc.</section>

LONSURF

trifluridine

tipiracil

tipiracil / trifluridine

tipiracil 6.14 MG / trifluridine 15 MG Oral Tablet

tipiracil 8.19 MG / trifluridine 20 MG Oral Tablet

Lonsurf

tipiracil 6.14 MG / trifluridine 15 MG Oral Tablet [Lonsurf]

tipiracil 8.19 MG / trifluridine 20 MG Oral Tablet [Lonsurf]

Psoriasis (PsO)

Psoriatic Arthritis (PsA)

Ankylosing Spondylitis (AS)

Nonradiographic Axial Spondyloarthritis

Taltz

Juvenile Idiopathic Arthritis

Hidradenitis Suppurativa (HS)

Cosentyx

Siliq

Tremfya

Crohn's Disease (CD)

Ulcerative Colitis (UC)

Stelara

Skyrizi

Ilumya

Migraine

Cluster Headache

Migraine Prevention

Emgality

Qulipta

Acute Migraine

Ubrelvy

Nurtec ODT

Vyepti

Aimovig

Ajovy

Breast Cancer: HR+ (HER2-)

Verzenio

Ibrance

Kisqali

Atopic Dermatitis (Eczema)

Cibinqo

Eucrisa

Asthma (injectable)

Asthma OCS Dependent

Nasal Polyposis

Eosinophilic Esophagitis (EoE)

Prurigo Nodularis

Dupixent

Opzelura

Adbry

NSCLC ALK+ OR ROS1+ Disease

Lorbrena

Alecensa

Alunbrig

NSCLC cMET Mutation

Xalkori

Rheumatoid Arthritis (RA)

Xeljanz

Uveitis

Graft Versus Host Disease (GVHD)

Orencia

COVID-19 Treatment

Alopecia Areata

Olumiant

Multiple Sclerosis (MS)

Secondary Progressive Multiple Sclerosis

Zeposia

Rinvoq

Entyvio

Report Adverse Event 

Prescribing Information 

Prescribing Information - Spanish

Medication Guide 

Medication Guide - Spanish 

Submit MSL Request 

Pharmacy List 

Billing & Coding Guide 

Lonsurf Enrollment Form 

Lonsurf Enrollment Form - Spanish 

Tahio HCP Portal 

Coverage Authorization Request 

Coverage Authorization Appeals 

Enroll in Patient Savings Progam 

Patient Assistance Program 

Other HCP Resources 

Instructions For Use: Metastatic Colorectal Cancer

Instructions For Use: Metastatic GEJ/Gastric Cancer

About Lonsurf 

Taking Lonsurf 

Side Effects 

Taiho Oncology Patient Support

Patient Resources 

Patient & Caregiver Brochure 

Patient & Caregiver Brochure - Spanish 

Doctor Discussion Guide 

FAQs: Metastatic Colorectal Cancer & Metastatic GEJ/Gastric Cancer 