Parkinson Disease

<section class="Section" data-sectioncode="34089-3"><a name="S11"></a><a name="section-10"></a><p></p><h1>11 DESCRIPTION</h1><p class="First">NOURIANZ contains istradefylline, an adenosine receptor antagonist, which has a xanthine derivative structure. The chemical name is (<span class="Italics">E</span>)-8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1<span class="Italics">H</span>-purine-2,6-dione. Its molecular formula is C<span class="Sub">20</span>H<span class="Sub">24</span>N<span class="Sub">4</span>O<span class="Sub">4</span>. The molecular weight is 384.43. Istradefylline has the following structural formula:</p><div class="Figure"><img alt="Chemical Structure" src="nourianz-01.jpg"/></div><p>Istradefylline is a light yellow-green crystalline powder. Istradefylline has a dissociation constant (p<span class="Italics">K</span><span class="Sub">a</span>) of 0.78. The aqueous solubility of istradefylline is ~0.5 µg/mL across the physiological pH range and 0.6 µg/mL in water.</p><p>NOURIANZ tablets are intended for oral administration only. Each tablet contains 20 mg or 40 mg of istradefylline and the following inactive ingredients: crospovidone, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and polyvinyl alcohol. The film coating contains hypromellose, lactose monohydrate, polyethylene glycol 3350, titanium dioxide, triacetin, and the following dyes: iron oxide red and iron oxide yellow. Carnauba wax is used for polishing.</p></section>

NOURIANZ

istradefylline

istradefylline 20 MG Oral Tablet

Nourianz

istradefylline 20 MG Oral Tablet [Nourianz]

istradefylline 40 MG Oral Tablet

istradefylline 40 MG Oral Tablet [Nourianz]

Psoriasis (PsO)

Psoriatic Arthritis (PsA)

Ankylosing Spondylitis (AS)

Nonradiographic Axial Spondyloarthritis

Taltz

Juvenile Idiopathic Arthritis

Hidradenitis Suppurativa (HS)

Cosentyx

Siliq

Tremfya

Crohn's Disease (CD)

Ulcerative Colitis (UC)

Stelara

Skyrizi

Ilumya

Migraine

Cluster Headache

Migraine Prevention

Emgality

Qulipta

Acute Migraine

Ubrelvy

Nurtec ODT

Vyepti

Aimovig

Ajovy

Breast Cancer: HR+ (HER2-)

Verzenio

Ibrance

Kisqali

Atopic Dermatitis (Eczema)

Cibinqo

Eucrisa

Asthma (injectable)

Asthma OCS Dependent

Nasal Polyposis

Eosinophilic Esophagitis (EoE)

Prurigo Nodularis

Dupixent

Opzelura

Adbry

NSCLC ALK+ OR ROS1+ Disease

Lorbrena

Alecensa

Alunbrig

NSCLC cMET Mutation

Xalkori

Rheumatoid Arthritis (RA)

Xeljanz

Uveitis

Graft Versus Host Disease (GVHD)

Orencia

COVID-19 Treatment

Alopecia Areata

Olumiant

Multiple Sclerosis (MS)

Secondary Progressive Multiple Sclerosis

Zeposia

Rinvoq

Entyvio

Report Adverse Event 

Prescribing Information 

Medication Guide 

Pharmacy List 

Coverage Authorization Request 

Coverage Authorization Appeals 

Letter of Medical Necessity 

Nourianz Patient Assistance Program Application Form 

Nourianz Kyowa Kirin Cares Enrollment & Prescription Form 

Enroll in Patient Savings Program 

Other HCP Resources 

About Nourianz 

Taking Nourianz

Patient Resources 

FAQs: Parkinson's Disease 

Care Partner Support 

Instructions For Use: Parkinson's Disease 

Patient Brochure 

Doctor Discussion Guide 

Wellness Team Contact Information Sheet 

Goal Summary For Doctor Visit 