Janus Kinase Inhibitors

Janus Kinase Inhibitor

Arthritis, Rheumatoid

<section class="Section" data-sectioncode="34089-3"><a name="s95"></a><a name="section-9"></a><p></p><h1>11 DESCRIPTION</h1><p class="First">OLUMIANT (baricitinib) is a Janus kinase (JAK) inhibitor with the chemical name {1-(ethylsulfonyl)-3-[4-(7<span class="Italics">H</span>-pyrrolo[2,3-<span class="Italics">d</span>]pyrimidin-4-yl)-1<span class="Italics">H</span>-pyrazol-1-yl]azetidin-3-yl}acetonitrile. Baricitinib has an empirical formula of C<span class="Sub">16</span>H<span class="Sub">17</span>N<span class="Sub">7</span>O<span class="Sub">2</span>S and a molecular weight of 371.42. Baricitinib has the following structural formula:</p><div class="Figure"><a name="f01"></a><img alt="Structural Formula
" src="olumiant-uspi-chem-v1.jpg"/></div><p>OLUMIANT tablets contain a recessed area on each face of the tablet surface and are available for oral administration as debossed, film-coated tablets. The 1 mg tablet is very light pink, round, debossed with “Lilly” on one side and “1” on the other. The 2 mg tablet is light pink, oblong, debossed with “Lilly” on one side and “2” on the other. The 4 mg tablet is medium pink, round, debossed with “Lilly” on one side and “4” on the other.</p><p>Each tablet contains 1, 2, or 4 mg of baricitinib and the following inactive ingredients: croscarmellose sodium, ferric oxide, lecithin (soya), magnesium stearate, mannitol, microcrystalline cellulose, polyethylene glycol, polyvinyl alcohol, talc and titanium dioxide.</p></section>

Olumiant

baricitinib

baricitinib 2 MG Oral Tablet

baricitinib 2 MG Oral Tablet [Olumiant]

baricitinib 1 MG Oral Tablet

baricitinib 1 MG Oral Tablet [Olumiant]

baricitinib 4 MG Oral Tablet

baricitinib 4 MG Oral Tablet [Olumiant]

Psoriasis (PsO)

Psoriatic Arthritis (PsA)

Ankylosing Spondylitis (AS)

Nonradiographic Axial Spondyloarthritis

Taltz

Juvenile Idiopathic Arthritis

Hidradenitis Suppurativa (HS)

Cosentyx

Siliq

Tremfya

Crohn's Disease (CD)

Ulcerative Colitis (UC)

Stelara

Skyrizi

Ilumya

Migraine

Cluster Headache

Migraine Prevention

Emgality

Qulipta

Acute Migraine

Ubrelvy

Nurtec ODT

Vyepti

Aimovig

Ajovy

Breast Cancer: HR+ (HER2-)

Verzenio

Ibrance

Kisqali

Atopic Dermatitis (Eczema)

Cibinqo

Eucrisa

Asthma (injectable)

Asthma OCS Dependent

Nasal Polyposis

Eosinophilic Esophagitis (EoE)

Prurigo Nodularis

Dupixent

Opzelura

Adbry

NSCLC ALK+ OR ROS1+ Disease

Lorbrena

Alecensa

Alunbrig

NSCLC cMET Mutation

Xalkori

Rheumatoid Arthritis (RA)

Xeljanz

Uveitis

Graft Versus Host Disease (GVHD)

Orencia

COVID-19 Treatment

Alopecia Areata

Multiple Sclerosis (MS)

Secondary Progressive Multiple Sclerosis

Zeposia

Rinvoq

Entyvio

Olumiant tablets are used to treat rheumatoid arthritis, alopecia areata, and COVID-19 in certain patients. These conditions are caused by an overactive immune system that causes inflammation. Olumiant works by blocking a specific protein that causes inflammation, which helps relieve symptoms. It is classified as a Janus kinase inhibitor (JAK inhibitor). In rheumatoid arthritis, the immune system attacks healthy joint tissues causing inflammation, and Olumiant reduces this inflammation to relieve joint pain, swelling, and tenderness. In alopecia areata, hair loss is caused by inflammation of the hair follicles, and Olumiant treats this inflammation to help hair regrow. However, Olumiant is not a cure for alopecia areata, and stopping the tablets may cause hair loss to return.

Report Adverse Event

Prescribing Information 

Medication Guide 

Pharmacy List 

Submit MSL Request 

Online Sample Form 

Coverage Authorization Request

Coverage Authorization Appeals

Letter of Medical Necessity 

PA Guide

Coverage Authorization Resource Guide: Alopecia Areata

Coverage Authorization Appeals - Editable Letter 

Letter of Medical Necessity - Editable Letter 

Enroll in Patient Savings Program 

Olumiant Together Enrollment Form: Dermatology 

Olumiant Together Enrollment Form: Rheumatology 

Lilly Cares Foundation Eligibility Check 

Lilly Cares Patient Assistance Program Application: Online

Lilly Cares Patient Assistance Program Application: English 

Lilly Cares Patient Assistance Program Application: Spanish 

Where to Order Olumiant From for Inpatient Network Distribution: COVID-19

Reimbursement of Olumiant For Treatment of COVID-19 In The Inpatient Setting

Access for Olumiant: COVID-19

About Olumiant: Rheumatoid Arthritis 

About Olumiant: Alopecia Areata

Olumiant Together 

Lilly Together App

Taking Olumiant & Side Effects 

Instructions For Use: Rheumatoid Arthritis 

Instructions For Use: Alopecia Areata

Instructions For Use: COVID-19