Diabetes Mellitus, Type 2

<section class="Section" data-sectioncode="34089-3"><a name="s11"></a><a name="section-10"></a><h1>11 DESCRIPTION</h1>Saxagliptin is an orally-active inhibitor of the DPP-4 enzyme.Saxagliptin monohydrate is described chemically as (1S,3S,5S)-2-[(2S)-2-Amino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile, monohydrate or (1S,3S,5S)-2-[(2S)-2-Amino-2-(3-hydroxyadamantan-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile hydrate. The empirical formula is C18H25N3O2•H2O and the molecular weight is 333.43. The structural formula is:<div class="Figure"><a name="id1050"></a><img alt="Saxagliptin Chemical Structure" src="saxagliptin-struct.jpg"/></div>Saxagliptin monohydrate is a white to light yellow or light brown, non-hygroscopic, crystalline powder. It is sparingly soluble in water at 24°C ± 3°C, slightly soluble in ethyl acetate, and soluble in methanol, ethanol, isopropyl alcohol, acetonitrile, acetone, and polyethylene glycol 400 (PEG 400).Each film-coated tablet of ONGLYZA for oral use contains either 2.79 mg saxagliptin hydrochloride (anhydrous) equivalent to 2.5 mg saxagliptin or 5.58 mg saxagliptin hydrochloride (anhydrous) equivalent to 5 mg saxagliptin and the following inactive ingredients: lactose monohydrate, microcrystalline cellulose, croscarmellose sodium, and magnesium stearate. In addition, the film coating contains the following inactive ingredients: polyvinyl alcohol, polyethylene glycol, titanium dioxide, talc, and iron oxides.</section>

ONGLYZA

saxagliptin

saxagliptin 5 MG Oral Tablet

Onglyza

saxagliptin 5 MG Oral Tablet [Onglyza]

saxagliptin 2.5 MG Oral Tablet

saxagliptin 2.5 MG Oral Tablet [Onglyza]

Psoriasis (PsO)

Psoriatic Arthritis (PsA)

Ankylosing Spondylitis (AS)

Nonradiographic Axial Spondyloarthritis

Taltz

Juvenile Idiopathic Arthritis

Hidradenitis Suppurativa (HS)

Cosentyx

Siliq

Tremfya

Crohn's Disease (CD)

Ulcerative Colitis (UC)

Stelara

Skyrizi

Ilumya

Migraine

Cluster Headache

Migraine Prevention

Emgality

Qulipta

Acute Migraine

Ubrelvy

Nurtec ODT

Vyepti

Aimovig

Ajovy

Breast Cancer: HR+ (HER2-)

Verzenio

Ibrance

Kisqali

Atopic Dermatitis (Eczema)

Cibinqo

Eucrisa

Asthma (injectable)

Asthma OCS Dependent

Nasal Polyposis

Eosinophilic Esophagitis (EoE)

Prurigo Nodularis

Dupixent

Opzelura

Adbry

NSCLC ALK+ OR ROS1+ Disease

Lorbrena

Alecensa

Alunbrig

NSCLC cMET Mutation

Xalkori

Rheumatoid Arthritis (RA)

Xeljanz

Uveitis

Graft Versus Host Disease (GVHD)

Orencia

COVID-19 Treatment

Alopecia Areata

Olumiant

Multiple Sclerosis (MS)

Secondary Progressive Multiple Sclerosis

Zeposia

Rinvoq

Entyvio

Report Adverse Event 

Pharmacy List 

Formulary Information

Reimbursement Information

Coverage Authorization Request 

Coverage Authorization Appeals 

Enroll in Patient Savings Program 

Rebate Form - Mail Order Patients 

Other HCP Resources 

Patient Brochure 

Managing Your Type 2 Diabetes 

What Are Your Numbers Telling You? Brochure 

What Are Your Numbers Telling You? Brochure - Spanish

About Onglyza

Taking Onglyza

Side Effects

FAQs: Type 2 Diabetes 

Onglyza Diabetes Care Partners

Doctor Discussion Guide 

Instructions For Use: Type 2 Diabetes