N-Calcium Channel Receptor Antagonists

N-type Calcium Channel Antagonist

Chronic Pain

<section class="Section" data-sectioncode="34089-3"><a name="s36"></a><a name="section-10"></a><p></p><h1>11 DESCRIPTION</h1><p class="First">PRIALT contains ziconotide, a synthetic equivalent of a naturally occurring conopeptide found in the piscivorous marine snail, <span class="Italics">Conus magus.</span> Ziconotide is a 25 amino acid, polybasic peptide containing three disulfide bridges with a molecular weight of 2639 daltons and a molecular formula of C<span class="Sub">102</span>H<span class="Sub">172</span>N<span class="Sub">36</span>O<span class="Sub">32</span>S<span class="Sub">7</span>. The amino acid sequence and disulfide bridging pattern are given below:</p><div class="Figure"><a name="f01"></a><img alt="Figure
" src="pri02-0000-01.jpg"/></div><p>Ziconotide is a hydrophilic molecule that is freely soluble in water and is practically insoluble in methyl t-butyl ether.</p><p>PRIALT is formulated as a sterile, preservative-free, isotonic solution for intrathecal administration using an appropriate microinfusion device [<span class="Italics">see Dosage and Administration (<a href="#s3">2</a>)</span>]. Each 1 or 5 mL vial of PRIALT (100 mcg/mL) respectively contains 100 or 500 mcg of ziconotide acetate, and the 20 mL vial of PRIALT (25 mcg/mL) contains 500 mcg of ziconotide acetate, with L-methionine and sodium chloride as excipients at pH 4.0–5.0. Each vial is intended for single use only, either undiluted or after dilution to the appropriate concentration with 0.9% Sodium Chloride Injection, USP (preservative free).</p></section>

PRIALT

1 ML ziconotide acetate 0.1 MG/ML Injection

1 ML ziconotide acetate 0.1 MG/ML Injection [Prialt]

5 ML ziconotide acetate 0.1 MG/ML Injection

5 ML ziconotide acetate 0.1 MG/ML Injection [Prialt]

ziconotide acetate

20 ML ziconotide acetate 0.025 MG/ML Injection

Prialt

20 ML ziconotide acetate 0.025 MG/ML Injection [Prialt]

ziconotide

Psoriasis (PsO)

Psoriatic Arthritis (PsA)

Ankylosing Spondylitis (AS)

Nonradiographic Axial Spondyloarthritis

Taltz

Juvenile Idiopathic Arthritis

Hidradenitis Suppurativa (HS)

Cosentyx

Siliq

Tremfya

Crohn's Disease (CD)

Ulcerative Colitis (UC)

Stelara

Skyrizi

Ilumya

Migraine

Cluster Headache

Migraine Prevention

Emgality

Qulipta

Acute Migraine

Ubrelvy

Nurtec ODT

Vyepti

Aimovig

Ajovy

Breast Cancer: HR+ (HER2-)

Verzenio

Ibrance

Kisqali

Atopic Dermatitis (Eczema)

Cibinqo

Eucrisa

Asthma (injectable)

Asthma OCS Dependent

Nasal Polyposis

Eosinophilic Esophagitis (EoE)

Prurigo Nodularis

Dupixent

Opzelura

Adbry

NSCLC ALK+ OR ROS1+ Disease

Lorbrena

Alecensa

Alunbrig

NSCLC cMET Mutation

Xalkori

Rheumatoid Arthritis (RA)

Xeljanz

Uveitis

Graft Versus Host Disease (GVHD)

Orencia

COVID-19 Treatment

Alopecia Areata

Olumiant

Multiple Sclerosis (MS)

Secondary Progressive Multiple Sclerosis

Zeposia

Rinvoq

Entyvio

Report Adverse Event 

Prescribing Information 

Submit MSL Request 

Pharmacy List 

Coverage Authorization Request 

Coverage Authorization Appeals 

Prialt Prescription & TeraSera Support Enrollment Form 

Enroll in Patient Savings Program 

Other HCP Resources 

About Prialt 

Nurse Support 

Instructions For Use: Pain Management 

Patient Brochure 

Doctor Discussion Guide 