Get your patient on Pyridostigmine Bromide - Pyridostigmine Bromide tablet (Pyridostigmine Bromide)
Pyridostigmine Bromide - Pyridostigmine Bromide tablet prescribing information
DOSAGE AND ADMINISTRATION
Pyridostigmine Bromide Tablets contain 60 mg pyridostigmine bromide each.
Dosage
The size and frequency of the dosage must be adjusted to the needs of the individual patient.
The average dose is ten 60 mg tablets daily spaced to provide maximum relief when maximum strength is needed. In severe cases as many as 25 tablets a day may be required, while in mild cases one to six tablets a day may suffice.
NOTE: For information on a diagnostic test for myasthenia gravis, and for the evaluation and stabilization of therapy, please see product literature on Tensilon (edrophonium chloride).
CONTRAINDICATIONS
Pyridostigmine Bromide Tablets are contraindicated in mechanical intestinal or urinary obstruction, and particular caution should be used in its administration to patients with bronchial asthma. Care should be observed in the use of atropine for counteracting side effects, as discussed below.
ADVERSE REACTIONS
The side effects of Pyridostigmine Bromide Tablets are most commonly related to overdosage and generally are of two varieties, muscarinic and nicotinic. Among those in the former group are nausea, vomiting, diarrhea, abdominal cramps, increased peristalsis, increased salivation, increased bronchial secretions, miosis and diaphoresis. Nicotinic side effects are comprised chiefly of muscle cramps, fasciculation and weakness. Muscarinic side effects can usually be counteracted by atropine, but for reasons shown in the preceding section the expedient is not without danger. As with any compound containing the bromide radical, a skin rash may be seen in an occasional patient. Such reactions usually subside promptly upon discontinuance of the medication.
To report SUSPECTED ADVERSE REACTIONS, contact Oceanside Pharmaceuticals at 1-800-321-4576 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
DESCRIPTION
Pyridostigmine Bromide Tablets, USP is an orally active cholinesterase inhibitor. Chemically, pyridostigmine bromide is 3-hydroxy-1-methylpyridinium bromide dimethylcarbamate. Its structural formula is:
Pyridostigmine bromide is available as tablets containing 60 mg pyridostigmine bromide; each tablet also contains lactose, silicon dioxide and stearic acid.
HOW SUPPLIED
Pyridostigmine Bromide Tablets, USP are available containing 60 mg of pyridostigmine bromide each in bottles of 100 (NDC 68682-302-10). Each tablet is cross-scored on one side and engraved "OCEANSIDE 302" on the other side.
Store Pyridostigmine Bromide Tablets at 25°C (77°F); excursions permitted to 15° to 30°C (59° to 86°F). Keep Pyridostigmine Bromide Tablets in a dry place with the silica gel enclosed.
