What is the dosage of Prograf?

Prograf is available in 3 dosages, including 0.5 mg Cap, 1 mg Cap and 5 mg Cap

What does Prograf treat?

Prograf treats Atopic Dermatitis and Graft vs Host Disease

Prograf contains tacrolimus which is a undefined

Prograf is administered as a Oral Pill

(tacrolimus)

tacrolimus 0.5 MG Oral Capsule [Prograf]tacrolimus 1 MG Oral Capsule [Prograf]

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ADULT
Patient Population	Initial OralDosage (formulation)	Whole Blood Trough Concentration Range
Kidney Transplant
With azathioprine	0.2 mg/kg/day capsules, divided in two doses, every 12 hours	Month 1 to 3: 7 to 20 ng/mL Month 4 to 12: 5 to 15 ng/mL
With MMF/IL-2 receptor antagonist	0.1 mg/kg/day capsules, divided in two doses, every 12 hours	Month 1 to 12: 4 to 11 ng/mL
Liver Transplant
With corticosteroids only	0.1 to 0.15 mg/kg/day capsules, divided in two doses, every 12 hours	Month 1 to 12: 5 to 20 ng/mL
Heart Transplant
With azathioprine or MMF	0.075 mg/kg/day capsules, divided in two doses, every 12 hours	Month 1 to 3: 10 to 20 ng/mL Month ≥ 4: 5 to 15 ng/mL
Lung Transplant
With azathioprine or MMF	0.075 mg/kg/day1 capsules, divided in two doses, every 12 hous	Month 1 to 3: 10 to 15 ng/mLMonth 4 to 12: 8 to 12 ng/mL
PEDIATRIC
Liver Transplant
	0.15 to 0.2 mg/kg/day capsules divided in two doses, every 12 hours	Month 1 to 12: 5 to 20 ng/mL
Lung Transplant	0.3 mg/kg/day2 capsules divided in two doses, every 12 hours	Weeks 1 to 2: 10 to 20 ng/mLWeek 2 to Month 12: 10 to 15 ng/mL

MMF= Mycophenolate mofetil

1Patients with cystic fibrosis may require higher doses due to lower bioavailability.

2 0.1 mg/kg/day if cell depleting induction treatment is administered.

•Intravenous (IV) use recommended for patients who cannot tolerate oral formulations (capsules). (2.1, 2.2)

• Administer capsules consistently with or without food.

• Therapeutic drug monitoring is recommended.

• Avoid eating grapefruit or drinking grapefruit juice.

• See dosage adjustments for African-American patients , hepatic and renal impaired.

• For complete dosing information, see the full prescribing information.

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