Dosage & Administration Drug label People also ask

Prograf

(tacrolimus)

tacrolimus 0.5 MG Oral Capsule [Prograf]tacrolimus 1 MG Oral Capsule [Prograf]

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Dosage & administration

Patient Population	Initial Oral Dosage (formulation)	Whole Blood Trough Concentration range
ADULT
Kidney Transplant
with azathioprine	0.2 mg/kg/day capsules divided in two doses, every 12 hours	Month 1-3: 7-20 ng/mL Month 4-12: 5-15 ng/mL
With MMF/IL-2 receptor antagonist	0.1 mg/kg/day capsules, divided in two doses, every 12 hours	Month 1-12: 4-11 ng/mL
Liver Transplant
With corticosteroids only	0.1-0.15 mg/kg/day capsules, divided in two doses, every 12 hours	Month 1-12: 5-20 ng/mL
Heart Transplant
With azathioprine or MMF	0.075 mg/kg/day capsules, divided in two doses, every 12 hours	Month 1-3: 10-20 ng/mL Month ≥ 4: 5-15 ng/mL
PEDIATRIC
Kidney Transplant
	0.3 mg/kg/day capsules, divided in two doses, every 12 hours	Month 1-12: 5-20 ng/mL
Liver Transplant
	0.15-0.2 mg/kg/day capsules 0.2 mg/kg/day, divided in two doses, every 12 hours	Month 1-12: 5-20 ng/mL
Heart Transplant	0.3 mg/kg/day* capsules divided in two doses, every 12 hours	Month 1-12: 5-20 ng/mL

MMF= Mycophenolate mofetil

*0.1 mg/kg/day if cell depleting induction treatment is administered

* Administer capsules consistently with or without food. ( 2.1)
* Therapeutic drug monitoring is recommended. ( 2.1, 2.6)
* Avoid eating grapefruit or drinking grapefruit juice. ( 2.1)
* See dosing adjustments for African-American patients ( 2.2), hepatic and renal impaired. ( 2.4, 2.5)
* For complete dosing information see the full prescribing information

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Prograf prescribing information

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Prograf FAQs

How is the dosage of Prograf?Prograf is available in 3 dosages, including 0.5 mg Cap, 1 mg Cap and 5 mg Cap

What does Prograf treat?Prograf treats Atopic Dermatitis and Graft vs Host Disease

How Is Prograf Administered?Prograf is administered as a Oral Pill

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