Insulin Analog

Diabetes Mellitus, Type 1

Diabetes Mellitus, Type 2

Hyperglycemia

<section class="Section" data-sectioncode="34089-3"><a name="ID_3ffdbc05-b63c-4358-981a-3156279b2692"></a><a name="section-10"></a><h1>11 DESCRIPTION</h1>Insulin degludec is a long-acting basal human insulin analog for subcutaneous injection produced by a process that includes expression of recombinant DNA in Saccharomyces cerevisiae followed by chemical modification.Insulin degludec differs from human insulin in that the amino acid threonine in position B30 has been omitted and a side-chain consisting of glutamic acid and a C16 fatty acid has been attached (chemical name: LysB29(Nε-hexadecandioyl-γ-Glu) des(B30) human insulin). Insulin degludec has a molecular formula of C274H411N65O81S6 and a molecular weight of 6.104 kDa. It has the following structure:Figure 1: Structural Formula of Insulin Degludec<div class="Figure"><a name="id1201"></a><img alt="Figure 1: Structural Formula of Tresiba" src="image-01.jpg"/></div>TRESIBA (insulin degludec) injection is a sterile, aqueous, clear, and colorless solution available as 100 units/mL (U-100) or 200 units/mL (U-200) for subcutaneous use. For the 100 units/mL solution, each mL contains 100 units of insulin degludec and glycerin (19.6 mg), metacresol (1.72 mg), phenol (1.5 mg), zinc (32.7 mcg), and Water for Injection, USP.For the 200 units/mL solution, each mL contains 200 units of insulin degludec and glycerin (19.6 mg), metacresol (1.72 mg), phenol (1.5 mg), zinc (71.9 mcg), and Water for Injection, USP.TRESIBA has a pH of approximately 7.6. Hydrochloric acid or sodium hydroxide may be added to adjust pH. </section>

Tresiba

insulin degludec

3 ML insulin degludec 100 UNT/ML Pen Injector

3 ML insulin degludec 100 UNT/ML Pen Injector [Tresiba]

3 ML insulin degludec 200 UNT/ML Pen Injector

3 ML insulin degludec 200 UNT/ML Pen Injector [Tresiba]

insulin degludec 100 UNT/ML Injectable Solution

insulin degludec 100 UNT/ML Injectable Solution [Tresiba]

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