Xeljanz

Q: What is the dosage of Xeljanz?

Xeljanz is available in 4 dosages, including 10 mg Tab, 11 mg 24 HR XR Tab, 22 mg 24 HR XR Tab and 5 mg Tab

Q: What does Xeljanz treat?

Xeljanz treats Rheumatoid Arthritis

Q: What is Xeljanz made of?

Xeljanz contains tofacitinib which is a Janus Kinase Inhibitor

Q: How is Xeljanz administered?

Xeljanz is administered as a Oral Pill

Q: What is Xeljanz mechanism of action?

Xeljanz mechanism of action is Janus Kinase Inhibitors

(tofacitinib)

24 HR tofacitinib 11 MG Extended Release Oral Tablet [Xeljanz]24 HR tofacitinib 22 MG Extended Release Oral Tablet [Xeljanz]

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BLACK BOX WARNING

Dosage & administration

Administration Instructions

* XELJANZ XR (tofacitinib extended-release tablets) is not interchangeable or substitutable with XELJANZ Oral Solution.
* Changes between XELJANZ and XELJANZ XR should be made by the healthcare provider.
* Do not initiate XELJANZ/XELJANZ XR/XELJANZ Oral Solution if absolute lymphocyte count <500 cells/mm3, an absolute neutrophil count (ANC) <1000 cells/mm3 or hemoglobin <9 g/dL.

Recommended Dosage

Rheumatoid Arthritis

* XELJANZ 5 mg twice daily or XELJANZ XR 11 mg once daily.
* Recommended dosage in patients with moderate and severe renal impairment or moderate hepatic impairment is XELJANZ 5 mg once daily.

Psoriatic Arthritis (in combination with nonbiologic DMARDs)

* XELJANZ 5 mg twice daily or XELJANZ XR 11 mg once daily.
* Recommended dosage in patients with moderate and severe renal impairment or moderate hepatic impairment is XELJANZ 5 mg once daily.

Ankylosing Spondylitis

* XELJANZ 5 mg twice daily or XELJANZ XR 11 mg once daily.
* Recommended dosage in patients with moderate and severe renal impairment or moderate hepatic impairment is XELJANZ 5 mg once daily.

Ulcerative Colitis

* Induction: XELJANZ 10 mg twice daily or XELJANZ XR 22 mg once daily for 8 weeks; evaluate patients and transition to maintenance therapy depending on therapeutic response. If needed, continue XELJANZ 10 mg twice daily or XELJANZ XR 22 mg once daily for a maximum of 16 weeks. Discontinue XELJANZ 10 mg twice daily or XELJANZ XR 22 mg once daily after 16 weeks if adequate therapeutic response is not achieved.
* Maintenance: XELJANZ 5 mg twice daily or XELJANZ XR 11 mg once daily. For patients with loss of response during maintenance treatment, XELJANZ 10 mg twice daily or XELJANZ XR 22 mg once daily may be considered and limited to the shortest duration, with careful consideration of the benefits and risks for the individual patient. Use the lowest effective dose needed to maintain response.
* Dosage adjustment is needed in patients with moderate and severe renal impairment or moderate hepatic impairment: see full prescribing information.

Polyarticular Course Juvenile Idiopathic Arthritis

* XELJANZ/XELJANZ Oral Solution 5 mg twice daily or weight-based equivalent twice daily.
* Dosage adjustment is needed in patients with moderate and severe renal impairment or moderate hepatic impairment: see full prescribing information.

Dosage Adjustment

* See the full prescribing information for dosage adjustments by indication for patients receiving CYP2C19 and/or CYP3A4 inhibitors; in patients with moderate or severe renal impairment or moderate hepatic impairment; and patients with lymphopenia, neutropenia, or anemia.
* Use of XELJANZ/XELJANZ XR/XELJANZ Oral Solution in patients with severe hepatic impairment is not recommended in any patient population.

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Xeljanz prescribing information

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Xeljanz FAQs

How is the dosage of Xeljanz?Xeljanz is available in 4 dosages, including 10 mg Tab, 11 mg 24 HR XR Tab, 22 mg 24 HR XR Tab and 5 mg Tab

What does Xeljanz treat?Xeljanz treats Rheumatoid Arthritis

What is Xeljanz made of?Xeljanz contains tofacitinib which is a Janus Kinase Inhibitor

How Is Xeljanz Administered?Xeljanz is administered as a Oral Pill

What Are The Xeljanz Mechanism Of Action?Xeljanz mechanism of action is Janus Kinase Inhibitors

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Xeljanz

Dosage & administration

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Xeljanz prescribing information

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