Androgen Receptor Antagonists

Androgen Receptor Inhibitor

Cytochrome P450 3A4 Inducers

Cytochrome P450 2C9 Inducers

Cytochrome P450 2C19 Inducers

Prostatic Neoplasms

<section class="Section" data-sectioncode="34089-3"><a name="i4i_description_id_19b4fdbd-4453-411a-b18c-234a57b1870c"></a><a name="section-10"></a><p></p><h1>11  DESCRIPTION</h1><p class="First">Enzalutamide is an androgen receptor inhibitor. The chemical name is 4-{3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-sulfanylideneimidazolidin-1-yl}-2-fluoro-<span class="Italics">N</span>-methylbenzamide.</p><p>The molecular weight is 464.44 and molecular formula is C<span class="Sub">21</span>H<span class="Sub">16</span>F<span class="Sub">4</span>N<span class="Sub">4</span>O<span class="Sub">2</span>S. The structural formula is:</p><div class="Figure"><a name="id449594699"></a><img alt="Structural formula of Enzalutamide" src="image-01.jpg"/></div><p>Enzalutamide is a white crystalline non-hygroscopic solid. It is practically insoluble in water.</p><p>XTANDI is available as liquid-filled soft gelatin capsules for oral administration. Each capsule contains 40 mg of enzalutamide as a solution in caprylocaproyl polyoxylglycerides. The inactive ingredients are caprylocaproyl polyoxylglycerides, butylated hydroxyanisole, butylated hydroxytoluene, gelatin, sorbitol sorbitan solution, glycerin, purified water, titanium dioxide, and black iron oxide.</p><p>XTANDI is also available as film-coated tablets for oral administration. Each tablet contains 40 mg or 80 mg of enzalutamide. The inactive ingredients are hypromellose acetate succinate, microcrystalline cellulose, colloidal silicon dioxide, croscarmellose sodium, and magnesium stearate. The tablet film-coat contains hypromellose, talc, polyethylene glycol, titanium dioxide, and ferric oxide.</p></section>

Xtandi

enzalutamide

enzalutamide 40 MG Oral Capsule

enzalutamide 40 MG Oral Capsule [Xtandi]

enzalutamide 40 MG Oral Tablet

enzalutamide 40 MG Oral Tablet [Xtandi]

enzalutamide 80 MG Oral Tablet

enzalutamide 80 MG Oral Tablet [Xtandi]

Psoriasis (PsO)

Psoriatic Arthritis (PsA)

Ankylosing Spondylitis (AS)

Nonradiographic Axial Spondyloarthritis

Taltz

Juvenile Idiopathic Arthritis

Hidradenitis Suppurativa (HS)

Cosentyx

Siliq

Tremfya

Crohn's Disease (CD)

Ulcerative Colitis (UC)

Stelara

Skyrizi

Ilumya

Migraine

Cluster Headache

Migraine Prevention

Emgality

Qulipta

Acute Migraine

Ubrelvy

Nurtec ODT

Vyepti

Aimovig

Ajovy

Breast Cancer: HR+ (HER2-)

Verzenio

Ibrance

Kisqali

Atopic Dermatitis (Eczema)

Cibinqo

Eucrisa

Asthma (injectable)

Asthma OCS Dependent

Nasal Polyposis

Eosinophilic Esophagitis (EoE)

Prurigo Nodularis

Dupixent

Opzelura

Adbry

NSCLC ALK+ OR ROS1+ Disease

Lorbrena

Alecensa

Alunbrig

NSCLC cMET Mutation

Xalkori

Rheumatoid Arthritis (RA)

Xeljanz

Uveitis

Graft Versus Host Disease (GVHD)

Orencia

COVID-19 Treatment

Alopecia Areata

Olumiant

Multiple Sclerosis (MS)

Secondary Progressive Multiple Sclerosis

Zeposia

Rinvoq

Entyvio

Xtandi is an anti-androgen that functions by blocking the effects of androgens, which are male hormones.

Xtandi is prescribed for the treatment of prostate cancer.

It can be employed when the cancer is unresponsive to treatment but remains localized without spreading to other areas.

Xtandi is also an option when the cancer responds to treatment and has metastasized to other parts of the body.

Report Adverse Event 

Prescribing Information

Medication Guide 

Pharmacy List 

How To Order Xtandi 

Submit MSL Request 

Coverage Authorization Request 

Coverage Authorization Appeals 

Letter of Medical Necessity 

XTANDI Support Solutions Enrollment Form

Astellas Xtandi Support Solutions - HCP Online Portal 

Other HCP Resources - Forms 

Xtandi Quick Start Program - Max 14-Day Supply

Enroll in Patient Savings Program 

Astellas Patient Assistance Program 

Reimbursement Information

Patient Brochure 

Xtandi Support Solutions Brochure

Doctor Discussion Guide 

About Xtandi

Side Effects 

Taking Xtandi

Patient Stories 

FAQs: Prostate Cancer 

Patient Resources 

Xtandi Support Solutions

Instructions For Use: Prostate Cancer